{"product_id":"product_ff9977d8-d12a-49f3-87b8-87b52a808c36","title":"HSN - CHOLESTEROL CARE | 120caps","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHSN's EssentialSeries Cholesterol Care is an exclusive broad-spectrum formula developed by HSN's Research and Development department specifically for supporting blood cholesterol control, combining 11 active compounds in vegan capsules without aesthetic additives. The formula includes two patented ingredients (Vegapure® and BioPerine®), five highly concentrated and standardised plant extracts (Amla, Berberis aristata, Milk Thistle, Red Yeast Rice, Black Pepper), microencapsulated Astaxanthin from Haematococcus pluvialis, Coenzyme Q10, Policosanol from sugarcane, and two B vitamins (B1 and B12 methylcobalamin). The combination of these compounds covers multiple molecular pathways involved in cholesterol metabolism and cardiovascular health, in a complementary and synergistic way. Dosage: 2 vegan capsules twice a day before meals (4 capsules\/day). Vegan, non-GMO, no aesthetic additives or colourings.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVegapure® Phytosterols (800 mg\/day, 73.5% beta-sitosterol): the EFSA-approved health claim for normal blood cholesterol maintenance:\u003c\/strong\u003e Phytosterols (plant sterols) are compounds structurally analogous to cholesterol found in animals, but derived from plants (soy, rapeseed, pine). The EFSA has approved the health claim: phytosterols and phytostanols contribute to the maintenance of normal blood cholesterol levels, with the beneficial effect obtained with a minimum daily intake of 0.8 g. Cholesterol Care provides exactly this effective dose of 800 mg of phytosterols per day. The mechanism of action is competitive: phytosterols have a very similar structure to cholesterol and compete with it for incorporation into absorption micelles in the small intestine, reducing the amount of cholesterol (both dietary and bile-derived) that is absorbed into the bloodstream. Vegapure® is BASF's phytosterol raw material, internationally recognised for its quality and its high standardised content of beta-sitosterol (73.5%), the phytosterol with the greatest evidence base for reducing LDL cholesterol.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRed Yeast Rice (Monacolin K): a natural mechanism analogous to statins:\u003c\/strong\u003e Red yeast rice is produced by fermenting rice (Oryza sativa) with the fungus Monascus purpureus, which naturally produces a group of compounds called monacolins. Monacolin K, the most relevant compound, has a chemical structure identical to lovastatin (a statin class drug) and acts by the same mechanism: competitive inhibition of the HMG-CoA reductase enzyme, which is the rate-limiting step in the endogenous cholesterol synthesis pathway in the liver. By inhibiting this enzyme, Monacolin K reduces hepatic cholesterol production, which stimulates the liver to increase the expression of LDL receptors on the surface of hepatocytes, resulting in increased uptake of LDL from circulation and a consequent reduction in plasma LDL-cholesterol levels. The EFSA has approved the health claim: Monacolin K from red yeast rice contributes to maintaining normal blood cholesterol levels, with the beneficial effect obtained with a daily intake of 10 mg of Monacolin K. The Cholesterol Care formula is standardised to 3.75% Monacolin K in the red rice extract.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCoenzyme Q10: essential muscle and cardiovascular protection with Monacolin K:\u003c\/strong\u003e Coenzyme Q10 (CoQ10, ubiquinone) is an essential component of the mitochondrial electron transport chain, being fundamental for ATP production in all body cells, with a particular concentration in heart muscle and skeletal muscles. The inclusion of CoQ10 in the Cholesterol Care formula is especially relevant given that Monacolin K, by inhibiting HMG-CoA reductase, also inhibits the mevalonate synthesis pathway, which is a common precursor for both cholesterol and endogenous CoQ10. Supplementation with CoQ10 when using Monacolin K or statins is a widely recommended practice to compensate for CoQ10 depletion that can result from the inhibition of this pathway, especially to prevent myopathies (muscle pain) frequently associated with statin use.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBerberis aristata (Berberine 97%, 100:1): mechanism complementary to Monacolin K via AMPK and PCSK9:\u003c\/strong\u003e Berberis aristata bark extract standardised to 97% berberine HCl has complementary and distinct mechanisms of action to Monacolin K for LDL cholesterol reduction. Berberine activates the enzyme AMPK (AMP-activated protein kinase), which promotes the expression of LDL receptors in hepatocytes (increasing LDL uptake from circulation), and inhibits PCSK9 (Proprotein Convertase Subtilisin\/Kexin Type 9), the protease that degrades LDL receptors on the surface of hepatocytes. PCSK9 inhibition is the same mechanism of action as the newest monoclonal antibodies for cholesterol (evolocumab, alirocumab). The combination of Monacolin K (HMG-CoA reductase inhibition) with Berberine (AMPK activation and PCSK9 inhibition) results in coverage of three of the main molecular pathways of LDL regulation in a single product.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVegapure® Phytosterols + Milk Thistle + Amla: complementary liver and antioxidant protection:\u003c\/strong\u003e Milk Thistle (Silybum marianum) extract with 80% silymarin has documented hepatoprotective properties, with mechanisms that protect hepatocytes against oxidative damage, hepatic anti-inflammatory effects, and support for hepatic cell regeneration. Since the liver is the central organ of cholesterol metabolism, liver health is directly relevant to cholesterol regulation. Amla (Phyllanthus emblica, 60% hydrolysable tannins) extract is a broad-spectrum natural antioxidant with documented cardiovascular protective properties, inhibition of LDL oxidation (which is the critical step in the formation of atherosclerotic plaques), and modulation of lipid metabolism.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMicroencapsulated Astaxanthin from Haematococcus pluvialis: cardiovascular antioxidant and anti-inflammatory:\u003c\/strong\u003e Astaxanthin from Haematococcus pluvialis is a carotenoid with antioxidant properties far superior to most dietary antioxidants, with studies documenting antioxidant activity up to 6000 times greater than Vitamin C and 100 times greater than Vitamin E. In the cardiovascular context, astaxanthin has documented properties of inhibiting LDL oxidation (reducing the formation of oxidized LDL, which is the main trigger of atherosclerotic inflammation), modulating inflammatory cytokines, and improving endothelial function. The microencapsulation used in the formula protects astaxanthin (a very unstable fat-soluble carotenoid) from oxidation during storage, ensuring the potency declared on the label until the end of the shelf life.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSugarcane Policosanol: additional support for cholesterol metabolism via AMPK:\u003c\/strong\u003e Policosanol, extracted from sugarcane wax (Saccharum officinarum), is a mixture of long-chain aliphatic alcohols (mainly octacosanol) with properties supporting cholesterol metabolism via AMPK activation, similar to berberine but through distinct molecular mechanisms. Clinical studies with sugarcane policosanol document modest reductions in LDL-cholesterol and possible effects of increasing HDL-cholesterol.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBioPerine® (piperine 98.5%) to increase the bioavailability of all compounds:\u003c\/strong\u003e Piperine (Piper nigrum extract) patented by Sabinsa Corporation under the name BioPerine® is an inhibitor of phase I (CYP3A4, CYP1A2) and phase II (UGT) metabolising enzymes that are responsible for the metabolism and elimination of many bioactive plant compounds, such as berberine, silymarin, and other phytochemicals in Cholesterol Care. By inhibiting these first-pass enzymes, BioPerine® increases the oral bioavailability of all compounds with which it is co-administered, maximising the efficacy of each ingredient in the formula.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVitamin B1 and Vitamin B12 methylcobalamin for cardiovascular health:\u003c\/strong\u003e Vitamin B1 (thiamine) contributes to normal heart function. Vitamin B12 methylcobalamin (the active and most bioavailable form of cobalamin) contributes to normal homocysteine metabolism, reducing plasma homocysteine levels, an amino acid that, in high concentrations, is an independent risk factor for atherosclerotic cardiovascular disease.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 2 vegan capsules twice a day before main meals (total: 4 capsules\/day). Taking them before meals is especially relevant for phytosterols, which exert their cholesterol absorption-reducing effect directly on the subsequent meal.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705356284251,"sku":null,"price":34.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-CHOLESTEROLCARE.webp?v=1777498803","url":"https:\/\/brothers-club.com\/en\/products\/product_ff9977d8-d12a-49f3-87b8-87b52a808c36","provider":"Brother's Club","version":"1.0","type":"link"}