{"product_id":"product_ddd367be-b387-466e-9f04-f89d460f3718","title":"Life Pro - Vitamin B12 | 90caps","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLife Pro Nutrition Vitamin B12 is a single-ingredient food supplement in VCAPS vegetable capsules, containing \u003cstrong\u003e1000 µg (micrograms) of cyanocobalamin per capsule\u003c\/strong\u003e, the most stable, safest, and most clinically studied form of vitamin B12. Unlike most B12 supplements that recommend 1 capsule\/day, Life Pro follows scientific evidence on the pharmacokinetics of high-dose cyanocobalamin and recommends \u003cstrong\u003e2 doses of 1 capsule per week\u003c\/strong\u003e (2 separate days), totaling 2000 µg\/week. This bi-weekly high-dose regimen is metabolically more efficient than low daily doses, given that high-dose cyanocobalamin (\u003e500 µg) is absorbed primarily by passive diffusion (independent of intrinsic factor), and absorption by passive diffusion is proportional to the dose. 90 capsules (45 weeks of use at 2 capsules\/week). Vegan. Bacterial origin (non-animal).\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVitamin B12 and why its supplementation is especially critical in plant-based diets:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eVitamin B12 (cobalamin) is the only B vitamin not present in plants, fungi, or yeasts in forms bioavailable to humans. It is produced exclusively by bacteria and archaea, and reaches human tissues primarily via consumption of animal-derived foods (especially offal such as liver, shellfish, red meat, fish, eggs, and dairy products) that have concentrated the B12 produced by microorganisms in their gut. People following strict vegan diets (without any animal-derived foods) will inevitably develop B12 deficiency if they do not supplement, as there is no relevant amount of bioavailable plant-based B12. Life Pro Vitamin B12 is specifically formulated with \u003cstrong\u003ebacterial-derived cyanocobalamin\u003c\/strong\u003e (not derived from animal tissues), making it suitable for vegans and vegetarians.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eB12 deficiency and its consequences: why not underestimate this nutrient:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eVitamin B12 deficiency is one of the most insidious vitamin deficiencies: it develops slowly (the liver can store B12 for 2 to 5 years), initial symptoms are non-specific (fatigue, weakness, tingling in extremities, mood swings, difficulty concentrating) and can be confused with other conditions, and the neurological consequences of prolonged deficiency are potentially irreversible. Severe B12 deficiency causes two distinct types of damage: \u003cstrong\u003emegaloblastic anemia\u003c\/strong\u003e (abnormally large red blood cells and functionally deficient due to inability of normal cell division) and \u003cstrong\u003esubacute combined degeneration of the spinal cord\u003c\/strong\u003e (progressive demyelination of the posterior and lateral columns of the spinal cord, with ataxia, paresthesias, spasticity, and eventual dementia). Anemia is reversible with supplementation, but neurological lesions may only be partially reversible if the deficiency was prolonged.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCyanocobalamin: the preferred form for supplementation due to safety, stability, and documented absence of toxic dose:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThere are four main forms of vitamin B12 used in supplements: \u003cstrong\u003ecyanocobalamin\u003c\/strong\u003e, methylcobalamin, hydroxocobalamin, and adenosylcobalamin. Life Pro Vitamin B12 specifically uses \u003cstrong\u003ecyanocobalamin\u003c\/strong\u003e for the following technical and safety reasons. Cyanocobalamin is the most chemically stable form (resistant to light, heat, and humidity), with a longer shelf life and less degradation during storage. It also has the longest and most extensive clinical evidence base: studies on the prevention and treatment of B12 deficiency, EFSA reference values, and recommended doses in the literature are almost exclusively based on cyanocobalamin. Crucially, cyanocobalamin has \u003cstrong\u003eno documented toxic dose\u003c\/strong\u003e: being water-soluble, excess is excreted in the urine without accumulation in tissues, unlike forms like methylcobalamin which can have receptor saturation effects at very high doses. Cyanocobalamin is converted by the body into the active coenzymatic forms (methylcobalamin and adenosylcobalamin) inside cells, ensuring the availability of both functional forms.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe pharmacokinetics of cyanocobalamin and the justification for the bi-weekly 1000 µg dose:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eVitamin B12 has a dual intestinal absorption mechanism that is central to understanding optimal supplementation dosage. The primary mechanism is \u003cstrong\u003eintrinsic factor (IF)-mediated absorption\u003c\/strong\u003e: dietary B12 binds to IF (a glycoprotein produced by gastric parietal cells), and the B12-IF complex is absorbed in cubilin receptors in the terminal ileum with a maximum capacity of ~1.5 µg per meal (regardless of the ingested dose). The secondary mechanism is \u003cstrong\u003epassive diffusion\u003c\/strong\u003e: about 1 to 2% of any ingested B12 dose is absorbed by passive diffusion along the entire intestinal mucosa, independent of IF, and this mechanism is proportional to the dose without saturation. At doses of 1000 µg, ~10 µg are absorbed by passive diffusion (1% × 1000 µg), in addition to ~1.5 µg via IF, totaling ~11.5 µg absorbed per dose. This is why international public health authorities recommend 1000 µg of cyanocobalamin 2x\/week as a supplementation regimen for vegans instead of smaller daily doses: high-dose passive diffusion absorption 2x\/week is more efficient and reproducible than relying exclusively on IF absorption at low daily doses, especially in people with reduced IF production (elderly, people with atrophic gastritis, post-bariatric surgery).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe functions of vitamin B12 in the body: the two B12-dependent enzymatic reactions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eVitamin B12 is a cofactor for only \u003cstrong\u003etwo enzymes\u003c\/strong\u003e in the human body, but both are absolutely essential. The first is \u003cstrong\u003emethionine synthase\u003c\/strong\u003e (MS), which converts homocysteine to methionine using methylcobalamin as a cofactor (together with folic acid\/MTHFR). This reaction is essential for: the synthesis of SAM (S-adenosylmethionine, the body's main methyl group donor, essential for DNA methylation, histones, and neurotransmitters), the regeneration of tetrahydrofolate (THF) from 5-methylTHF (B12 deficiency \"traps\" folate in the methyl cycle, causing functional folic acid deficiency even when folate levels are adequate), and the synthesis of endogenous creatine (which requires methionine via SAM). The second is \u003cstrong\u003emethylmalonyl-CoA mutase\u003c\/strong\u003e (MUT), which converts methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin as a cofactor. This reaction is essential for the metabolism of branched-chain amino acids (valine, isoleucine), threonine, and odd-chain fatty acids, integrating these metabolites into the Krebs cycle via succinyl-CoA. MUT deficiency results in the accumulation of methylmalonyl-CoA and methylmalonic acid, which are toxic to myelin (hence the neurological degeneration of B12 deficiency).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eEnergy, nervous system, hematopoiesis, and melatonin: the approved EFSA claims:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eEFSA has approved the following health claims for vitamin B12: contribution to normal energy-yielding metabolism, to normal functioning of the nervous system, to normal psychological function, to the normal function of the immune system, to the reduction of tiredness and fatigue, to normal red blood cell formation, to normal DNA synthesis, and to normal homocysteine metabolism. B12 also has a documented role in the synthesis of \u003cstrong\u003emelatonin\u003c\/strong\u003e (the hormone of circadian rhythm and sleep), given that methionine (whose metabolism depends on B12) is the precursor of SAM which methylates serotonin to melatonin via N-acetylserotonin methyltransferase.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take \u003cstrong\u003e1 capsule twice a week\u003c\/strong\u003e, on two separate days (e.g., Monday and Thursday). Separating the two weekly doses by at least 3 days maximizes the absorption window via passive diffusion for each dose. It can be taken at any time of day, with or without food. For people with a confirmed diagnosis of B12 deficiency (by blood tests), an initial repletion phase with higher or more frequent doses may be necessary, to be adjusted with the attending physician.\u003c\/p\u003e","brand":"Life Pro","offers":[{"title":"Default Title","offer_id":52705359593819,"sku":null,"price":13.9,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/LifePro-VitaminB12.png?v=1776672574","url":"https:\/\/brothers-club.com\/en\/products\/product_ddd367be-b387-466e-9f04-f89d460f3718","provider":"Brother's Club","version":"1.0","type":"link"}