{"product_id":"product_cf31ff88-4d9b-43f9-b664-258dd30c79e7","title":"HSN - EVO 2:1:1 (BCAAs 2:1:1 + VITAMINS B6 AND B12) | 120caps","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eEVO 2:1:1 from HSN's SportSeries is a branched-chain amino acid (BCAA) supplement in fast-disintegrating tablets, formulated with the 2:1:1 ratio (L-Leucine: L-Isoleucine: L-Valine) most studied by science, obtained exclusively through vegetable fermentation. Each tablet provides 1g of pure BCAAs, without lacquering or coatings that delay disintegration, ensuring immediate release of amino acids for rapid absorption in the gastrointestinal tract. The formula is enriched with Vitamin B6 (pyridoxine hydrochloride) to support hormonal and protein metabolism, and Vitamin B12 in its active methylcobalamin form (the form the body uses directly, without the need for metabolic conversion) to reduce fatigue and tiredness. Vegan, gluten-free, no animal-derived ingredients. Available in packs of 30, 120, and 240 tablets.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBCAAs 2:1:1 from vegetable fermentation: the ratio most studied by science:\u003c\/strong\u003e Branched-Chain Amino Acids (BCAAs) are a group of three essential amino acids with a branched aliphatic side chain: L-Leucine, L-Isoleucine, and L-Valine. They are \"essential\" because the human body cannot synthesize them and must obtain them through diet or supplementation. The 2:1:1 ratio (2 parts Leucine to 1 part Isoleucine and 1 part Valine) is the ratio that most closely approximates the natural concentration of these amino acids in human muscle protein and is the most widely used in scientific studies on BCAAs, also being the natural proportion in which they are found in major high-quality protein sources (whey, casein, egg). HSN's BCAAs are obtained exclusively by microbial fermentation from plant sources, unlike many brands that still use extraction processes from poultry feathers, human hair, or other animal by-products, making EVO 2:1:1 completely suitable for vegan and vegetarian diets.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Leucine as the main activator of muscle protein synthesis via mTORC1:\u003c\/strong\u003e L-Leucine is the amino acid with the greatest and most direct ability to activate the mTORC1 pathway (mechanistic Target Of Rapamycin Complex 1), the main intracellular regulator of muscle protein synthesis. mTORC1 signaling by L-Leucine is the central molecular mechanism by which protein or BCAA consumption stimulates muscle protein synthesis, regardless of other anabolic signals such as insulin or growth factors. The double dose of L-Leucine in the 2:1:1 ratio (compared to L-Isoleucine and L-Valine) reflects the primary role of this amino acid in stimulating protein synthesis and is the reason why the 2:1:1 ratio is the most used in a sports context for this purpose.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Isoleucine for energy metabolism and muscle glucose uptake:\u003c\/strong\u003e L-Isoleucine has functional properties distinct from those of L-Leucine: in addition to its role in protein synthesis, L-Isoleucine stimulates glucose uptake by skeletal muscle through an insulin-independent mechanism (involving the translocation of GLUT4 transporters to the cell membrane), contributing to the supply of energy substrate during high-intensity exercise. This property makes L-Isoleucine especially relevant for consumption during prolonged or high-intensity training sessions, where maintaining muscle glucose availability is crucial for performance.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Valine to support energy metabolism and reduce central fatigue:\u003c\/strong\u003e L-Valine competes with tryptophan in crossing the blood-brain barrier through the same branched-chain amino acid transporters. Tryptophan is the precursor of serotonin, a neurotransmitter associated with the sensation of central fatigue during prolonged exercise. By competing with tryptophan for entry into the brain, BCAA supplementation (including L-Valine) can attenuate the increase in brain serotonin during exercise, contributing to the reduction of the perception of central fatigue and the maintenance of performance in long-duration exercises.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAnti-catabolic support during intense exercise and caloric deficit:\u003c\/strong\u003e During intense exercise and in contexts of caloric deficit (cutting diets, caloric restriction), the body may resort to muscle protein degradation (catabolism) as an energy source, especially through the oxidation of BCAAs by skeletal muscle. BCAA supplementation before or during training provides an exogenous substrate for this oxidation, potentially sparing endogenous muscle protein from degradation, with an anti-catabolic effect particularly relevant during cutting phases or fasted training.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVitamin B6 (pyridoxine hydrochloride) for protein metabolism and hormonal regulation:\u003c\/strong\u003e Vitamin B6 is an essential cofactor for over 100 enzymes in amino acid metabolism, directly participating in the metabolism of transaminases that allow for amino acid interconversion and utilization. As recognized by the EFSA, Vitamin B6 demonstrably contributes to normal protein and glycogen metabolism, normal cysteine synthesis, and the normal functioning of the nervous system. In the specific context of BCAAs, Vitamin B6 is a cofactor for branched-chain aminotransferase (BCAT) deamination enzymes that catalyze the first step of BCAA catabolism in peripheral tissues, facilitating their metabolic utilization.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVitamin B12 in its active methylcobalamin form to reduce fatigue and support neurological function:\u003c\/strong\u003e Vitamin B12 is included in EVO 2:1:1 in the form of methylcobalamin, the active and methylated form of cobalamin that the body uses directly without the need for metabolic conversion, unlike cyanocobalamin (the most common and cheapest form) which requires hepatic conversion before it can perform its functions. Methylcobalamin has higher bioavailability, greater tissue stability, and greater effectiveness in reducing fatigue. As recognized by the EFSA, Vitamin B12 demonstrably contributes to the reduction of tiredness and fatigue, the normal functioning of the nervous system, and normal energy metabolism.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eFast-disintegrating tablets without lacquering for immediate absorption:\u003c\/strong\u003e The uncoated (unlacquered) tablet format and lack of modified-release agents ensure rapid disintegration in the stomach, with immediate release of amino acids for intestinal absorption. This feature is particularly relevant for peri-workout use, where the speed of amino acid availability in circulation is crucial for the supplement's effectiveness. Each tablet provides 1g of BCAAs in a highly concentrated format, the result of a manufacturing process that controls particle size and powder density to maximize the amount of amino acid per tablet.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePre-workout:\u003c\/strong\u003e Take 5 to 10 tablets (5 to 10g of BCAAs) with water 30 minutes before training to increase plasma amino acid availability during the session and reduce exercise-induced muscle catabolism.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIntra-workout:\u003c\/strong\u003e Take 5 tablets during long sessions (more than 60 to 90 minutes) to maintain plasma BCAA levels and reduce central fatigue and catabolism during prolonged effort.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePost-workout:\u003c\/strong\u003e Take 5 to 10 tablets immediately after training in combination with a complete protein source (whey, EAAs) to enhance the muscle protein synthesis stimulus in the post-workout window.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eFasted:\u003c\/strong\u003e Take 5 tablets upon waking to mitigate protein catabolism from overnight fasting, especially in morning fasted training protocols.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705355727195,"sku":null,"price":13.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/1_582f8434-2c7a-4d64-b4f0-e3a90ad99d96.png?v=1780699324","url":"https:\/\/brothers-club.com\/en\/products\/product_cf31ff88-4d9b-43f9-b664-258dd30c79e7","provider":"Brother's Club","version":"1.0","type":"link"}