{"product_id":"product_cceea25d-3595-4f76-838e-00bacc40c04c","title":"HSN - SAMe | 200mg","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHSN's EssentialSeries SAMe 200 mg is a dietary supplement in delayed-release DRCaps® vegetable capsules (Lonza) based on S-adenosyl-L-methionine (SAMe) in its most stable available form: microencapsulated tosylate disulfate. SAMe is an endogenous molecule produced mainly in the liver, synthesized from the essential amino acid L-methionine and ATP, which participates as a cofactor in over 100 biochemical reactions in the body, functioning as the primary universal methyl group donor in human cellular metabolism. The formula is complemented with Choline Bitartrate, Vitamin C (ascorbic acid), Cupric Gluconate (Copper), and Vitamin B12 (methylcobalamin), compounds that work synergistically with SAMe in methylation pathways, liver health, and homocysteine metabolism. Lonza's DRCaps® capsules are delayed-release vegetable capsules (HPMC) that protect SAMe from the acidic gastric environment, ensuring its intact arrival in the small intestine where it is absorbed. 1 capsule daily on an empty stomach. Vegan, allergen-free, non-GMO.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSAMe: the universal methyl group donor and cofactor for over 100 biochemical reactions:\u003c\/strong\u003e SAMe (S-adenosyl-L-methionine, also written S-adenosylmethionine) is an endogenous metabolite synthesized in the body mainly in the liver by the enzyme methionine adenosyltransferase (MAT), which conjugates L-methionine with ATP to form SAMe. It is the second most commonly used compound as an enzymatic cofactor in the human body (after ATP), participating as a methyl group donor in over 100 methylation reactions that encompass virtually all biological systems: neurotransmitter synthesis (serotonin, dopamine, norepinephrine, melatonin), membrane phospholipid synthesis (phosphatidylcholine, phosphatidylserine), DNA methylation (epigenetic regulation of gene expression), carnitine synthesis, creatine synthesis, glutathione synthesis (via trans-sulfuration), and homocysteine metabolism. SAMe levels decrease with aging, in contexts of folate and Vitamin B12 deficiency, and in liver diseases.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMicroencapsulated tosylate disulfate form: the most stable form for effective supplementation:\u003c\/strong\u003e SAMe in its free form (S-adenosyl-L-methionine base) is an extremely unstable compound that degrades rapidly on contact with oxygen, humidity, light, and gastric acid. The production of stable SAMe for oral supplementation requires chemical stabilization: the tosylate disulfate form is the most chemically stable SAMe salt commercially available, and it is the form used in the vast majority of SAMe clinical studies. Additional microencapsulation protects SAMe from oxidation during storage and gastrointestinal transit, and Lonza's DRCaps® capsules ensure that the capsule does not dissolve in the acidic environment of the stomach (pH 1 to 3) but only in the small intestine (pH 6 to 7), where SAMe is efficiently absorbed without acidic degradation. This combination of stable chemical form + microencapsulation + delayed-release capsule represents the most advanced SAMe protection technology available.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for mood and psychological well-being via neurotransmitter synthesis:\u003c\/strong\u003e SAMe is an essential cofactor for enzymes that convert the amino acid L-DOPA into dopamine (via methyl group donation to the COMT enzyme, catechol-O-methyltransferase) and for the N-acetylation of serotonin into melatonin. The synthesis of serotonin, dopamine, and norepinephrine directly depends on the availability of SAMe as a methyl group donor in the methylation reactions of these pathways. Clinical studies with SAMe in the context of mood support document mood and psychological well-being improvement effects, with documented mechanisms of action on the monoaminergic system. Meta-analyses document that SAMe at 800 to 1600 mg\/day produced superior effects to placebo in several clinical trials for mood support.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for joint health: comparative clinical studies with NSAIDs:\u003c\/strong\u003e Two clinical studies evaluated in a 2002 meta-analysis (Soeken et al.) documented that SAMe (600 mg\/day orally, twice daily) was as effective as NSAIDs (non-steroidal anti-inflammatory drugs like diclofenac and ibuprofen) in improving functional limitations in patients with knee and hip osteoarthritis, but without the gastrointestinal and cardiovascular adverse effects of NSAIDs. The mechanism of action in articular cartilage involves stimulating proteoglycan synthesis by chondrocytes (via methylation and glycosaminoglycan synthesis) and anti-inflammatory properties (via inhibition of inflammatory cytokine synthesis). This profile of efficacy comparable to conventional therapies but with much greater safety makes SAMe especially relevant for adults seeking natural alternatives to chronic NSAID use.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for liver health and protection against cholestasis:\u003c\/strong\u003e The liver is the organ with the highest concentration of SAMe in the body (where it is primarily synthesized) and its hepatic functions are multiple and critical: participation in phosphatidylcholine synthesis (essential for hepatocyte membrane integrity and for lipid transport in bile), support for hepatic glutathione synthesis (via trans-sulfuration, SAMe is converted to cysteine, the limiting precursor of glutathione), and maintenance of biliary fluidity. In contexts of liver dysfunction (intrahepatic cholestasis, alcoholic hepatitis, cirrhosis), hepatic SAMe levels are often depleted, compromising these protective functions. Clinical studies with intravenous and oral SAMe in intrahepatic cholestasis of pregnancy and in alcoholic cirrhosis document improvements in markers of liver injury and biliary function.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCholine bitartrate: synergistic support for hepatic lipid metabolism and methylation:\u003c\/strong\u003e The choline included in the formula as bitartrate (one of the most stable and bioavailable forms) is a precursor to the methyl group donor metabolite betaine, which can regenerate homocysteine to methionine (and consequently to SAMe) via the betaine-homocysteine methyltransferase (BHMT) pathway. This pathway is complementary to the folate\/B12 pathway for homocysteine remethylation, and it is especially active in the liver. Choline also has EFSA-approved health claims for normal hepatic lipid metabolism and for the maintenance of normal liver function, being especially relevant for preventing the accumulation of liver fat (steatosis).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMethylcobalamin Vitamin B12 and Vitamin C: essential cofactors of the SAMe cycle:\u003c\/strong\u003e Vitamin B12 (methylcobalamin, the active form) is an essential cofactor of methionine synthase, the enzyme that remethylates homocysteine to methionine (the direct precursor of SAMe) in the folate-dependent pathway. Without sufficient B12, the methionine-SAMe-homocysteine-methionine cycle is compromised, leading to homocysteine accumulation and SAMe depletion. Vitamin C (ascorbic acid) plays an antioxidant protective role for SAMe, given that SAMe is a molecule sensitive to oxidation, and Vitamin C can reduce the rate of oxidative degradation of SAMe during gastrointestinal transit after the DRCaps® capsule opens in the intestine.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCopper (cupric gluconate): cofactor for copper-dependent enzymes relevant to the SAMe cycle:\u003c\/strong\u003e Copper is a cofactor for multiple enzymes that have a functional relationship with SAMe metabolism, including lysyl oxidase (which uses SAMe for collagen and elastin maturation), ceruloplasmin, and cupric-zinc superoxide dismutase (Cu\/Zn-SOD), which is an enzymatic antioxidant that complements the antioxidant protection of SAMe.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eDirections for Use\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 capsule daily, preferably on an empty stomach (30 minutes before meals), to maximize SAMe absorption without food interference. The dose of 200 mg\/day is the maintenance dose; for joint support, clinical studies typically used 600 to 1200 mg\/day (take 3 to 6 capsules\/day in divided doses, following professional advice).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e After opening, store in a cool (below 25°C), dry, and dark place. SAMe is sensitive to humidity, heat, and light: close the package tightly after each use.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705356841307,"sku":null,"price":47.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-SAMe_200mg.webp?v=1777503713","url":"https:\/\/brothers-club.com\/en\/products\/product_cceea25d-3595-4f76-838e-00bacc40c04c","provider":"Brother's Club","version":"1.0","type":"link"}