{"product_id":"product_b45fb92f-2086-4cf6-9bd6-8bd1afe74876","title":"HSN - NAC (N-ACETYL-L-CYSTEINE) | 300mg","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHSN's EssentialSeries NAC (N-Acetyl-L-Cysteine) 300 mg is a food supplement in vegetable capsules based on N-Acetyl-L-Cysteine (NAC), the acetylated version of the semi-essential amino acid L-cysteine, produced by plant fermentation. NAC is one of the supplements with the greatest versatility of documented clinical applications, being simultaneously the main orally available precursor of glutathione, a mucolytic agent used clinically, a direct antioxidant, a support for liver health and a nootropic with documented effects on cognitive function. HSN's formula is enriched with natural Vitamin E (D-alpha-tocopheryl succinate), Riboflavin (Vitamin B2) and Selenium (L-selenomethionine), three micronutrients with complementary antioxidant properties and EFSA approved health claims. Pack of 120 capsules (4 months of supplementation). 1 capsule per day. Vegan, gluten-free and GMO-free.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eNAC as a glutathione precursor: the most effective way to raise endogenous GSH levels:\u003c\/strong\u003e N-Acetyl-L-Cysteine is the most effective orally available glutathione precursor in supplementation. L-cysteine is the limiting amino acid for glutathione (GSH) synthesis, being the one with the lowest relative availability in the body compared to glutamate and glycine (the other two amino acid components of the tripeptide). By providing L-cysteine in acetylated form (which has much higher oral bioavailability and gastrointestinal stability than free L-cysteine), NAC increases the intracellular availability of cysteine and, consequently, the rate of endogenous glutathione synthesis in all cells of the body. The strategic advantage of NAC over direct supplementation with reduced glutathione (GSH) is that NAC stimulates intracellular GSH synthesis, which is the biologically relevant location, while exogenous glutathione has difficulty being absorbed intact and crossing cell membranes to effectively exert its function.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDirect antioxidant due to the reactivity of the free thiol group:\u003c\/strong\u003e In addition to its role as a glutathione precursor, NAC has direct antioxidant activity thanks to the free thiol group (-SH) in its molecular structure, which can directly neutralise free radicals and reactive oxygen species (ROS). This direct antioxidant activity is independent of NAC's role as a GSH precursor and adds an immediate layer of antioxidant protection that complements the more delayed but sustained effect of increased intracellular GSH levels.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for liver health and detoxification:\u003c\/strong\u003e The liver is the organ with the highest concentration of glutathione in the body, using it as an essential cofactor for phase II detoxification enzymes (glutathione S-transferases) that conjugate and eliminate xenobiotics, toxins, medications and heavy metals. NAC is widely recognised for its role in supporting liver health, being used clinically in the treatment of paracetamol (acetaminophen) poisoning, where the depletion of hepatic glutathione is the central mechanism of hepatotoxicity. Daily NAC supplementation maintains hepatic glutathione reserves, supporting the liver's detoxification capacity and protecting hepatocytes against oxidative damage associated with alcohol, chronic medication, exposure to pesticides and pollutants, and chronic metabolic stress.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMucolytic properties for respiratory health:\u003c\/strong\u003e NAC has one of the most well-documented clinical applications in respiratory health, being used as a mucolytic agent in clinical medicine since the 1960s. The mechanism of action is direct: NAC breaks the disulfide bonds between bronchial mucus glycoproteins, reducing its viscosity and elasticity and facilitating its elimination from the respiratory tract through productive coughing and mucociliary clearance. This mucolytic effect is relevant for both chronic respiratory conditions (chronic bronchitis, COPD, idiopathic pulmonary fibrosis) and acute situations of excessive mucus accumulation associated with viral or bacterial respiratory infections.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCognitive support and neuroprotection:\u003c\/strong\u003e Glutathione plays a relevant role in central nervous system health, being one of the main cerebral antioxidants and a protector of neuronal cells against oxidative stress. NAC, by increasing GSH levels in the brain, can contribute to neuronal protection and the maintenance of cognitive function, especially in contexts of high cerebral oxidative stress associated with ageing, chronic fatigue or post-intense exercise recovery. Exploratory studies with NAC in neuropsychiatric disorders document effects of mood improvement, anxiety reduction and cognitive function improvement, attributed to the modulation of cerebral redox balance and the modulation of neurotransmitters such as glutamate.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eNatural Vitamin E (D-alpha-tocopheryl succinate) for antioxidant protection of membranes:\u003c\/strong\u003e The natural Vitamin E included in the formula in its most bioavailable form (D-alpha-tocopheryl succinate) is the main fat-soluble antioxidant of cell membranes, protecting phospholipids from lipid peroxidation. As recognised by EFSA, Vitamin E demonstrably contributes to the protection of cells against oxidative stress. The combination of NAC (which increases intracellular water-soluble GSH) with Vitamin E (which protects lipid membranes) covers the two main antioxidant compartments of the cell.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRiboflavin (Vitamin B2) for glutathione metabolism and cellular energy:\u003c\/strong\u003e Riboflavin (Vitamin B2) is an essential cofactor of glutathione reductase, the enzyme responsible for regenerating oxidised glutathione (GSSG) back to its active reduced form (GSH). Without sufficient Riboflavin, the capacity for GSH regeneration is compromised, even if precursors are available. The inclusion of Riboflavin in the formula completes the glutathione support cycle: NAC provides the precursor (cysteine) for GSH synthesis, Riboflavin ensures the regeneration of oxidised GSH, and Vitamin E and Selenium protect against oxidative stress that consumes GSH.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSelenium (L-selenomethionine) as a cofactor for glutathione peroxidase:\u003c\/strong\u003e Selenium is an essential trace mineral and an indispensable cofactor for the glutathione peroxidase (GPx) family of enzymes, which uses GSH to neutralise hydrogen peroxides and lipid peroxides. Without sufficient Selenium, GPx activity is compromised, regardless of GSH availability. L-selenomethionine is the organic form of Selenium with the highest bioavailability and stability, as recognised by EFSA for contributing to the protection of cells against oxidative stress and to the normal functioning of the immune system.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eProduction by plant fermentation: vegan and without ingredients of animal origin:\u003c\/strong\u003e The NAC used by HSN is produced by microbial fermentation from plant sources, ensuring that the product is 100% suitable for vegan and vegetarian diets, without any ingredients of animal origin in its composition or production process.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 capsule daily with a meal. For higher doses (600 to 1200 mg\/day) as recommended by most studies, take 2 to 4 capsules spread throughout the day with meals.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSynergistic combinations recommended by HSN:\u003c\/strong\u003e For maximum support for glutathione production, combine with Glycine (the third amino acid component of GSH, often deficient in older adults). For specific liver support, combine with Milk Thistle (silymarin). For cardiovascular antioxidant support, combine with Coenzyme Q10. For immune support, combine with Vitamin C and Zinc.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a cool (below 25°C), dry and dark place. Keep out of reach of children.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705355661659,"sku":null,"price":9.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-NAC_300mg.webp?v=1777501415","url":"https:\/\/brothers-club.com\/en\/products\/product_b45fb92f-2086-4cf6-9bd6-8bd1afe74876","provider":"Brother's Club","version":"1.0","type":"link"}