Amix - ThermoCore | 90caps

About the Product

Amix's ThermoCore™ is a thermogenic and fat-burning supplement in capsules, developed with a formula of 7 active ingredients that combine thermogenic, lipolytic, and fatty acid mobilization mechanisms to support body fat loss within the context of a caloric deficit and regular physical exercise. The formula combines Coleus Forskohlii 250 mg (10% forskolin), Green Coffee 250 mg, Anhydrous Caffeine 160 mg, Guarana 200 mg (22% caffeine), Salix Alba 200 mg (15% salicin), Citrus Aurantium 10 mg (95% synephrine), and BioPerine® 5 mg (patented black pepper extract to improve bioavailability). This is a significantly stimulating formula with multiple complementary mechanisms of action, aimed at athletes and adults experienced with supplementation.

Benefits

Coleus Forskohlii (250 mg, 10% forskolin) for lipolysis activation via cAMP: Coleus Forskohlii is a plant from the mint family whose active compound, forskolin, directly activates the enzyme adenylate cyclase, increasing intracellular levels of cyclic AMP (cAMP). cAMP is the second messenger responsible for activating hormone-sensitive lipase (HSL), the enzyme that catalyzes lipolysis (the breakdown of triglycerides in adipose tissue into free fatty acids and glycerol). This mechanism of action is distinct from and complementary to that of caffeine and synephrine, which act on adrenergic receptors, allowing for lipolysis activation through two different pathways simultaneously. Additionally, forskolin has been investigated for its role in supporting muscle mass maintenance during weight loss phases.

Caffeine (160 mg anhydrous + caffeine from Guarana 200 mg at 22%) for thermogenesis and fat mobilization: ThermoCore™ provides caffeine through two complementary pathways: fast-absorbing anhydrous caffeine (plasma peak in 45 to 60 minutes) and natural caffeine bound to the fiber of guarana seeds (Paullinia cupana), which is released more slowly and gradually over 3 to 5 hours, prolonging the thermogenic and stimulating effect without the energy crash associated with isolated anhydrous caffeine. Caffeine inhibits phosphodiesterases, enzymes that degrade cAMP, enhancing and prolonging the effect of forskolin in activating hormone-sensitive lipase. The total caffeine dose per serving includes the contribution of anhydrous caffeine and natural guarana caffeine, placing it at a moderate to significant stimulation level.

Green Coffee for metabolic acceleration and glucose absorption modulation: Green coffee extract (unroasted coffee beans) is rich in chlorogenic acid, a polyphenol that inhibits hepatic glucose-6-phosphatase, modulating glucose release by the liver and postprandial insulin response. This action on glucose metabolism complements the lipolytic effects of the other ingredients in the formula, contributing to better nutrient partitioning (greater utilization of fat as an energy substrate relative to glucose) during exercise and at rest.

Citrus Aurantium (10 mg, 95% synephrine) for beta-3 adrenergic receptor activation: Citrus Aurantium extract standardized to 95% synephrine is the most commonly used ephedrine substitute in modern thermogenic formulas. Synephrine preferentially acts on beta-3 adrenergic receptors in adipose tissue, which mediate lipolysis and adaptive thermogenesis, with less impact on cardiovascular beta-1 and alpha-1 receptors compared to ephedrine. The 10 mg dose of 95% synephrine extract in ThermoCore™ is calculated for a significant thermogenic effect, especially in synergistic combination with caffeine.

Salix Alba (200 mg, 15% salicin) for potentiation and prolongation of the thermogenic effect: Salicin, the active compound in white willow bark extract (Salix Alba), is the natural precursor of salicylic acid. Salicin inhibits the synthesis of prostaglandins that oppose the thermogenic effects of adrenaline and noradrenaline, prolonging the activity window of the lipolytic stimuli from the other ingredients in the formula. This combination of caffeine + synephrine + salicin is known in sports nutrition literature as the "natural ECA stack" (Ephedrine-Caffeine-Aspirin natural equivalent), being one of the most documented for fat loss support.

BioPerine® (5 mg) for maximizing the bioavailability of all ingredients: BioPerine® is a patented black pepper extract (Piper nigrum) standardized to 95% piperine, with a documented effect of increasing the oral bioavailability of multiple nutrients and bioactive compounds, including those present in the ThermoCore™ formula. Piperine inhibits first-pass intestinal and hepatic enzymes (CYP3A4, P-glycoprotein) that degrade many compounds before they reach systemic circulation, resulting in higher plasma concentrations of the active ingredients with the same ingested dose.

Usage

Recommended dosage: Take the recommended capsules with water 30 to 45 minutes before training or main meals. Consult the packaging for the specific dose. Do not exceed the recommended daily dose. Do not take within 6 hours before sleep.

Usage cycles: Use in cycles of 8 to 12 weeks with a subsequent break of at least 4 weeks, to prevent desensitization of adrenergic receptors to stimulating and thermogenic effects.

Storage: Store in a cool, dry place, away from sunlight and moisture. Keep out of reach of children.