About the Product
HSN's EssentialSeries Rutin 500 mg is a food supplement in vegetable capsules based on naturally sourced rutin, extracted from the flower buds of Sophora japonica (Japanese pagoda tree), with an 8:1 extraction ratio and standardized to 98% pure rutin. Rutin is a flavonol (bioflavonoid) present in various fruits, vegetables, and plants, with the flower buds of Sophora japonica before blooming being the natural source with the highest known rutin density, making this plant the raw material of choice for supplementation with this compound. The formula is enriched with Magnesium Citrate (highly bioavailable) and Selenium (L-selenomethionine), two micronutrients with antioxidant properties and nervous system support complementary to those of rutin. Each capsule provides 500 mg of 98% rutin, equivalent to ~8163 mg of Sophora japonica bud extract. Dosage: 1 capsule 1 to 2 times a day with meals (500 to 1000 mg of rutin/day). Vegan, gluten-free, non-GMO.
Benefits
Rutin: the Sophora japonica flavonol with antioxidant, vascular, and anti-inflammatory properties: Rutin (also called rutoside or quercetin 3-O-rutinoside) is a glycoside flavonol formed by the union of quercetin with the disaccharide rutinose. It is one of the most studied bioflavonoids in scientific literature, with documented antioxidant, anti-inflammatory, venoprotective, and anticoagulant properties. Rutin belongs to the flavonol family, the same subfamily as quercetin, with which it shares the structural core and many of its biological properties, being the most abundant natural quercetin glycoside in plants. Sophora japonica is the natural source with the highest concentration of rutin available, especially in closed flower buds before blooming, where rutin serves as an energy reserve compound for the flowering process.
Protection and reinforcement of capillary and vascular integrity: The most classic and documented property of rutin is its role in strengthening the integrity of blood capillary walls. Rutin inhibits hyaluronidase, the enzyme that degrades hyaluronic acid, which is part of the extracellular matrix of capillary vessels, contributing to the maintenance of mechanical resistance and selective impermeability of capillary walls. This action results in reduced capillary fragility, lower permeability to water and plasma proteins (reducing edema), and lower susceptibility to bruise formation from minor trauma. These properties are especially relevant for people with capillary fragility, easy bruising, chronic venous insufficiency, and hemorrhoidal problems.
Direct antioxidant activity and cellular protection against oxidative stress: Rutin is a potent free radical scavenger antioxidant, capable of neutralizing reactive oxygen species (ROS) and nitrogen species (RNS), chelating transition metal ions (such as iron and copper) that catalyze oxidative Fenton reactions, and activating endogenous antioxidant defense pathways (Nrf2). Its antioxidant activity is amplified in vivo by conjugation with quercetin (which is the product of rutin deglycosidation by intestinal microbiota), as both molecules have complementary antioxidant activity. Studies document that rutin supplementation increases plasma markers of total antioxidant capacity and reduces markers of lipid peroxidation.
Modulation of inflammation and reduction of pro-inflammatory cytokines: Rutin has documented anti-inflammatory properties in multiple experimental models, acting on the inhibition of inflammatory enzymes (COX-1, COX-2, 5-LOX), the reduction of pro-inflammatory cytokine expression (IL-1β, TNF-α, IL-6), and the modulation of the nuclear factor NF-κB. Clinical and preclinical studies document that rutin in combination with other flavonoids (such as in the diosmin-hesperidin flavonoid mixture) is effective and safe for controlling bleeding associated with hemorrhoids, with patient satisfaction significantly higher than the placebo group.
Inhibition of platelet aggregation and circulation support: Rutin interferes with platelet activation through the inhibition of enzymes such as phosphodiesterase and protein kinase C, and by complexing calcium ions which are necessary for platelet activation signaling. This antiplatelet property is relevant for maintaining fluid blood circulation in contexts of high thromboembolic risk, although it should be used with caution in people already taking anticoagulant or antiplatelet medication.
Magnesium Citrate for fatigue reduction and nervous system support: The Magnesium Citrate included in the formula provides 77.5 mg of elemental magnesium per daily dose, in one of the forms with the highest bioavailability. As recognized by the EFSA, Magnesium demonstrably contributes to the reduction of tiredness and fatigue, to the normal functioning of the nervous and muscular system, and to the maintenance of normal bones. In the context of vascular and circulatory support, magnesium is especially relevant given its role in the relaxation of vascular smooth muscle and the regulation of blood pressure.
Selenium (L-selenomethionine) for cellular antioxidant protection: L-selenomethionine (the organic form of Selenium with the highest bioavailability) is an essential cofactor of glutathione peroxidase, the antioxidant enzyme that uses glutathione to neutralize lipid and hydrogen peroxides. As recognized by the EFSA, Selenium demonstrably contributes to the protection of cells against oxidative stress, synergistically complementing the direct antioxidant activity of rutin.
8:1 extract standardized to 98% Sophora japonica flower bud: the highest concentration available: The choice of Sophora japonica flower buds before opening is crucial for the quality of the extract, as this stage of plant development concentrates the highest density of rutin. The 8:1 extraction ratio and standardization to 98% rutin ensure that each 500 mg capsule provides an equivalent of ~8163 mg of native flower bud, with 98% of the capsule content being pure rutin, without dilution by other plant phytochemicals. This purity and concentration clearly distinguish this product from conventional rutin extracts with lower standardization and less source specificity.
Uses
Recommended dose: Take 1 capsule 1 to 2 times a day with meals. The dose of 1000 mg/day (2 capsules) is the dose used in most clinical studies for vascular and anti-inflammatory support. For use as a maintenance antioxidant, 500 mg/day (1 capsule) may be sufficient.
Timing: Taking with meals improves gastrointestinal tolerance and may improve absorption, as the presence of food stimulates gastrointestinal transit and the activity of digestive enzymes that process glycosylated flavonoids.
Synergistic combinations: For more comprehensive vascular support, combine with HSN's Vitamin C 1000 mg (which has complementary vascular strengthening properties and regenerates oxidized rutin). For a more complete bioflavonoid profile, HSN's Citrus Bioflavonoids Complex combines rutin with quercetin, citrus bioflavonoids, and Vitamin C in a single formula.
