About the Product
HSN's EssentialSeries Magnesium Malate 1000 mg is a dietary supplement in tablets based on pure magnesium malate, a form of magnesium combined with malic acid that stands out for its dual contribution: elemental Magnesium for its multiple physiological functions (with over 8 EFSA-approved health claims) and malic acid for its participation as a substrate in the Krebs Cycle for mitochondrial ATP production. Each 1000 mg magnesium malate tablet provides 115.5 mg of elemental Magnesium. A daily dose of 3 tablets provides 3000 mg of magnesium malate = 346.5 mg of elemental Magnesium, covering most adults' daily magnesium needs. Vegetarian and vegan. Gluten-free, GMO-free, allergen-free. HSN maintains full transparency in declaring elemental Magnesium content (not the total salt weight), distinguishing itself from brands that only declare the salt's weight.
Benefits
Magnesium Malate: the combination of magnesium with malic acid for mitochondrial energy and muscle support: Magnesium malate is an organic salt resulting from the combination of Magnesium ions (Mg2+) with malic acid (a 4-carbon dicarboxylic acid, also called malate in its ionic form). This combination is unique for simultaneously providing elemental Magnesium and bioavailable malic acid in a single molecule. Magnesium is an essential cofactor for mitochondrial ATPase and over 300 enzymes involved in energy metabolism, while malic acid is a central intermediary of the Krebs Cycle (Citric Acid Cycle), directly participating in the conversion of energy substrates (carbohydrates, fats, and proteins) into NADH and FADH2, which fuel the mitochondrial respiratory chain for ATP production. The synergy between Magnesium (enzymatic cofactor) and malic acid (metabolic substrate) makes magnesium malate particularly relevant for supporting energy metabolism and reducing muscle fatigue.
Over 8 EFSA-approved health claims for Magnesium: Magnesium has one of the most extensive portfolios of EFSA-approved health claims of any supplemental mineral. Magnesium demonstrably contributes to: the reduction of tiredness and fatigue, electrolyte balance, normal energy metabolism, normal functioning of the nervous system, normal muscle function, normal protein synthesis, normal psychological function, maintenance of normal bones and normal teeth. This wide range of proven functions reflects Magnesium's central role as a cofactor in over 300 enzymatic reactions that cover virtually all physiological systems of the human body.
Role of Magnesium in energy metabolism and mitochondrial function: ATP (adenosine triphosphate), the primary cellular energy currency, exists primarily as an intracellular Mg-ATP complex (magnesium-ATP). Magnesium is necessary for ATP stabilization and for the activity of all enzymes that use ATP as a substrate (ATPases), including Na+/K+-ATPase (essential for maintaining cellular membrane potential) and myosin ATPase (essential for muscle contraction). Magnesium depletion directly compromises the efficiency of ATP production and utilization, clinically manifesting as fatigue, muscle cramps, and reduced physical performance. Magnesium malate supplementation restores intracellular Magnesium levels, restoring the functional capacity of these enzymes.
Malic acid and specific support for fibromyalgia and chronic fatigue: Magnesium malate has a specific and unique clinical evidence base (not shared by other forms of magnesium) for support in conditions of chronic muscle fatigue, especially fibromyalgia. Fibromyalgia is characterized by chronic diffuse muscle pain and fatigue, with studies documenting magnesium and malic acid deficiencies in affected muscle fibers. A clinical study published in the Journal of Nutritional Medicine (Russell et al., 1995) with 15 fibromyalgia patients documented that magnesium malate supplementation (300 to 600 mg of Magnesium + 1200 to 2400 mg of malic acid/day) significantly reduced pain and tenderness scores after 8 weeks, with regression of effects after cessation. This specific result of magnesium malate (not replicated by other forms of magnesium in comparative studies) is attributed to the synergistic contribution of malic acid to mitochondrial function in muscle cells.
Support for the nervous system and psychological function: Magnesium plays a fundamental role in regulating neurotransmission in the central nervous system, acting as a natural antagonist of NMDA (N-methyl-D-aspartate) receptors, which are the main glutamate receptors in the CNS. In conditions of magnesium deficiency, NMDA receptors become hyperactive (as Magnesium physically blocks the NMDA ion channel at rest), contributing to anxiety, irritability, and hypersensitivity to stress. Magnesium supplementation restores the physiological blockade of NMDA, contributing to normal psychological function and the reduction of tiredness and mental fatigue as recognized by EFSA.
Support for muscle function, cramp prevention, and sports recovery: Magnesium is essential for muscle relaxation after contraction, as it functions as a physiological antagonist of calcium (which triggers muscle contraction). The intracellular Mg/Ca imbalance, which occurs due to both magnesium depletion and metabolic acidosis (exacerbated by intense exercise), is the primary mechanism of muscle cramps. Magnesium malate supplementation restores the Mg/Ca balance and, through malic acid, supports the elimination of lactate accumulated in muscle fibers during high-intensity exercise (malic acid is an intermediate that can capture pyruvate groups in the glucoplastic pathway, facilitating the exit of lactate from muscle fibers).
Transparency in labeling: 346.5 mg of elemental Magnesium from 3000 mg of magnesium malate: HSN maintains a policy of full transparency in declaring elemental Magnesium content, precisely calculated from the molecular composition of magnesium malate. Magnesium malate contains 11.55% elemental Magnesium by salt weight (calculated from the atomic masses of Mg=24.3 and the magnesium malate molecule), which represents 115.5 mg of elemental Magnesium per 1000 mg magnesium malate tablet, and 346.5 mg of elemental Magnesium in the daily dose of 3 tablets (3000 mg of magnesium malate). This transparency allows the user to correctly compare the actual Magnesium content with other products on the market.
Usage
Recommended dose: Take 1 tablet 3 times a day with meals (total: 3000 mg of magnesium malate/day = 346.5 mg of elemental Magnesium/day). Taking with meals improves gastrointestinal tolerance and magnesium absorption, as the presence of food stimulates gastric acid secretion, which facilitates the solubilization of the magnesium salt.
Timing for athletes: For recovery support and cramp prevention, take 1 tablet after training and 1 tablet at bedtime, in addition to the morning meal.
