{"product_id":"product_70efa8db-5f89-421b-bc65-caa1bce90210","title":"HSN - ZINC GLUCONATE | 120 caps (25mg zinc)","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHSN's EssentialSeries Zinc Gluconate 25 mg is a food supplement in plant-based tablets based on zinc gluconate, the zinc salt with the longest history of clinical use and the most extensive base of reference studies. Zinc gluconate is formed by the conjugation of zinc with gluconic acid (a carboxylic acid derived from glucose), resulting in a salt with good chemical stability, excellent gastrointestinal tolerance, and well-documented bioavailability in clinical trials. Each tablet provides 25 mg of elemental zinc (250% of the European NRV of 10 mg). Take 1 tablet daily with a meal. Clean label formula with the minimum necessary excipients. Vegan, gluten-free, non-GMO, allergen-free. Available in 120 and 365 tablets (4-month and 12-month supply).\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eZinc gluconate: the clinical reference form with the longest history of studies and use in supplementation:\u003c\/strong\u003e Zinc gluconate is historically the most widely used form of zinc in clinical trials and has the longest tradition in oral supplementation, especially in seminal studies on the role of zinc in immunity and in reducing the duration of common colds (studies with zinc gluconate lozenges). It is formed by the conjugation of zinc (Zn2+) with gluconic acid, with a proportion of ~14% elemental zinc by weight of the salt. Its long tradition of clinical use, consistent data on safety and gastrointestinal tolerance, and excellent chemical stability during storage have established zinc gluconate as the reference form against which newer forms of zinc (citrate, bisglycinate, picolinate) are typically compared in bioavailability studies. The study by Wegmüller et al. (2014) published in the Journal of Nutrition documented that zinc citrate and zinc gluconate have comparable bioavailability and are significantly superior to zinc oxide. The meta-analysis by Hemilä (2017) published in JRSM Open compared zinc acetate and zinc gluconate in lozenges for the common cold, documenting that both forms reduced the duration of colds.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMore than 10 EFSA-approved health claims for Zinc:\u003c\/strong\u003e Zinc is the trace element with the highest number of EFSA-approved health claims for any mineral supplement. Zinc is proven to contribute to: the protection of cells from oxidative damage, normal cognitive function, the normal functioning of the immune system, the maintenance of normal vision, the maintenance of normal skin, the maintenance of normal hair, the maintenance of normal nails, normal DNA synthesis, normal fatty acid metabolism, normal macronutrient metabolism, normal protein synthesis, normal vitamin A metabolism, the maintenance of normal bones, the maintenance of normal testosterone levels in the blood, normal male reproductive function, and normal bone development in children. This breadth reflects the central role of zinc as a cofactor for over 300 metalloproteins and over 1000 transcription factors that regulate gene expression in virtually all cell types of the human body.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eImmune support: role of Zinc in innate and adaptive immunity:\u003c\/strong\u003e Zinc is essential for the development and maturation of T lymphocytes in the thymus (thymulin, a thymic hormone regulating T lymphocyte maturation, is a metalloprotein with zinc in its active site), for antibody production by B lymphocytes, and for the cytotoxic activity of NK (Natural Killer) cells. Zinc deficiency causes thymic atrophy, marked suppression of cellular immunity, and increased susceptibility to bacterial, viral, and fungal infections. In the context of supporting the immune system against respiratory infections (flu, colds), studies with zinc gluconate lozenges documented reductions in the duration of colds by 28 to 40% compared to placebo when initiated within the first 24 hours after the onset of symptoms.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for the male reproductive system and testosterone:\u003c\/strong\u003e Zinc is a cofactor for 5-alpha-reductase (conversion of testosterone to dihydrotestosterone) and inhibits aromatase (conversion of testosterone to estradiol). Both mechanisms contribute to the maintenance of normal testosterone levels, as recognized by the approved EFSA health claim. Zinc is also essential for spermatogenesis: it selectively concentrates in the testes and seminal fluid, where it participates in sperm maturation and the protection of sperm DNA from oxidative damage. Zinc-deficient men often present with oligospermia reversible with supplementation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAntioxidant cell protection via Cu\/Zn-SOD and metallothioneins:\u003c\/strong\u003e Zinc is a cofactor for cytoplasmic copper-zinc superoxide dismutase (Cu\/Zn-SOD), one of the body's main enzymatic antioxidants. In addition, zinc induces the synthesis of metallothioneins (cysteine-rich proteins that chelate heavy metals such as cadmium, mercury, and lead, protecting cells from heavy metal toxicity) and stabilizes cell membranes against lipid peroxidation mediated by free radicals.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTablet format: maximum convenience and economy for long-term use:\u003c\/strong\u003e HSN's zinc gluconate is available in tablet format (not capsule), which allows for a more compact and economical presentation. Zinc gluconate tablets are very small (thanks to the high density of the salt), are easy to swallow, and have no perceptible taste (unlike some powdered forms of zinc). The 365-tablet supply represents a full year of supplementation in a single bottle, making it one of the most economical options for quality zinc supplementation on the Portuguese market.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 tablet daily with a meal. Taking it with a meal improves gastrointestinal tolerance and can slightly improve the absorption of zinc gluconate compared to taking it on an empty stomach, as the presence of protein-rich foods stimulates gastric acid secretion, which facilitates the dissolution of the salt.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705357201755,"sku":null,"price":7.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-GLUCONATODEZINCO_25mgZINCO.webp?v=1777499977","url":"https:\/\/brothers-club.com\/en\/products\/product_70efa8db-5f89-421b-bc65-caa1bce90210","provider":"Brother's Club","version":"1.0","type":"link"}