{"product_id":"product_64338849-00bf-4764-9607-0f17d4944273","title":"HSN - SUSTAINED-RELEASE CAFFEINE (CaffXtend) | 400mg","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eCaffeine Slow Release from HSN's EssentialSeries line is a food supplement in vegetable capsules based on CaffXtend®, Inventia Healthcare Ltd.'s granulated slow-release caffeine raw material, supplemented with pantothenic acid (Vitamin B5) and Vitamin B6. CaffXtend® is a patented granulation system that encapsulates natural anhydrous caffeine extracted from Coffea robusta beans in a modified-release matrix, completely altering caffeine's pharmacokinetic profile: while conventional immediate-release caffeine releases over 95% of its content within the first 5 minutes, CaffXtend® releases caffeine gradually and sustainedly over more than 12 hours, as documented by Inventia in comparative pharmacokinetic studies. CaffXtend® contains 50% pure caffeine by mass (the remaining 50% being the granulation matrix that provides the modified release): each capsule provides 400 mg of CaffXtend® = 200 mg of pure slow-release caffeine. 1 capsule per day, preferably in the morning. Vegan, gluten-free, GMO-free, allergen-free.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCaffXtend®: Inventia Healthcare's patented slow-release technology that transforms caffeine's pharmacokinetic profile:\u003c\/strong\u003e Conventional caffeine (anhydrous or natural immediate-release) has very rapid absorption pharmacokinetics, with plasma peak (Cmax) typically reached 30 to 60 minutes after ingestion, followed by a more gradual decline over 3 to 5 hours (caffeine plasma half-life of ~5 hours). This rapid peak-and-drop profile is suitable for short-term occasional use (1-2 hour workout, pre-workout), but has disadvantages for long-term use: the high peak often causes tremors, palpitations, and anxiety (especially in caffeine-sensitive individuals), and the abrupt drop in plasma concentrations 3 to 5 hours after intake is perceived as a \"caffeine crash\", with sudden fatigue and lack of concentration. CaffXtend® completely alters this profile through its granulation technology: caffeine is absorbed slowly over more than 12 hours, without a high peak and without an abrupt drop, resulting in a smoother, more sustained effect without the typical crash.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDirect clinical comparison: CaffXtend® vs immediate-release caffeine:\u003c\/strong\u003e The study by Thanawala et al. (2022), published in the Journal of Dietary Supplements, directly compared the bioavailability and effects on mental functions of CaffXtend® vs immediate-release caffeine in an open-label, randomized, crossover, single-dose trial in humans. The results document that slow-release caffeine (CaffXtend®) produced superior cognitive effects (alertness, concentration) from 4 to 8 hours after intake compared to immediate-release caffeine, whose cognitive effects had declined during that period. Immediate-release caffeine produced more intense effects in the first 1 to 2 hours, but with a rapid subsequent decline. This profile clearly favors CaffXtend® for uses requiring sustained alertness and concentration over 6 to 12 hours, such as prolonged workdays or long study sessions.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e200 mg of pure slow-release caffeine: the effective dose for alertness and concentration without excessive side effects:\u003c\/strong\u003e The 200 mg of pure caffeine per capsule represents the central dose used in most clinical studies of caffeine for cognitive and alertness effects, and is within the safety range established by EFSA (up to 400 mg\/day in healthy adults). Because it is slow-release, the 200 mg of caffeine in CaffXtend® produces much lower maximum plasma concentrations than 200 mg of immediate-release caffeine, which significantly reduces adverse effects related to high plasma peaks (tremors, tachycardia, anxiety) while maintaining the stimulating and focusing effect throughout the day.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePantothenic Acid (B5) for normal intellectual performance and neurotransmitter synthesis:\u003c\/strong\u003e The pantothenic acid included in the formula has EFSA-approved health claims especially relevant in the context of a cognitive support product: it is proven to contribute to normal intellectual performance, normal energy metabolism, and the normal synthesis and metabolism of steroid hormones, Vitamin D, and some neurotransmitters (especially acetylcholine, via acetyl-CoA synthesis which is the cofactor of choline acetyltransferase). This action of supporting neurotransmitter synthesis complements caffeine's stimulating effect at the level of cholinergic transmission, which is especially important for working memory and attention.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eVitamin B6 for fatigue reduction, energy metabolism, and nervous system function:\u003c\/strong\u003e Vitamin B6 (pyridoxine hydrochloride) is a cofactor for more than 100 enzymes involved in amino acid and neurotransmitter metabolism, with EFSA-approved health claims for: reduction of tiredness and fatigue, normal energy metabolism, and normal functioning of the nervous system. In the context of a slow-release cognitive support product, the inclusion of Vitamin B6 complements caffeine's stimulating effect with metabolic support for neuronal function.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLabeling transparency: 400 mg of CaffXtend® ≠ 400 mg of pure caffeine:\u003c\/strong\u003e HSN warns of a common misleading practice in the market: some manufacturers declare \"Caffeine (CaffXtend®) 400 mg\", leading the consumer to think they are receiving 400 mg of pure caffeine, when in reality CaffXtend® has only 50% caffeine by mass (the other 50% being the modified-release granulation matrix) and therefore 400 mg of CaffXtend® = 200 mg of pure caffeine. HSN declares with full transparency: 400 mg of CaffXtend® (50% pure caffeine) = 200 mg of pure slow-release caffeine, allowing the consumer to correctly compare the actual caffeine content with other products.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eUsage profile: study, work, and long-duration endurance sports:\u003c\/strong\u003e CaffXtend®'s slow-release profile makes it particularly suitable for three usage contexts. For students in long study sessions (4 to 8 hours), maintaining concentration and alertness throughout the entire period without a crash is the main benefit. For workers in long or cognitively demanding shifts, the same profile of maintaining alertness without an excessive initial peak or crash is crucial. For long-duration endurance athletes (ultramarathon, long-distance cycling, long-distance triathlon), the slow release ensures continuous caffeine availability throughout the event without the need for re-dosing.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 capsule per day, preferably in the morning with or without food. Given the caffeine release over up to 12 hours, it is recommended to take it early to minimize impact on night sleep.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTiming for different uses:\u003c\/strong\u003e For study or work: take upon waking or at the start of the workday\/study session. For long-duration endurance sports: take 30 to 60 minutes before starting the activity. Do not take after 2:00 PM to minimize the risk of interfering with night sleep, as the release extends for 12 hours.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705356218715,"sku":null,"price":24.45,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-CAFEINADELIBERTACAOPROLONGADA_CaffXtend.png?v=1776805092","url":"https:\/\/brothers-club.com\/en\/products\/product_64338849-00bf-4764-9607-0f17d4944273","provider":"Brother's Club","version":"1.0","type":"link"}