{"product_id":"product_5b6e031d-4687-4c2d-8fd6-7814157011df","title":"HSN - ZINC BISGLYCINATE | 120caps","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eZinc Bisglycinate 25 mg from HSN's EssentialSeries is a dietary supplement in vegetable capsules based on chelated zinc bisglycinate, the most orally bioavailable form of Zinc available for supplementation, enriched with Cupric Gluconate (1 mg of elemental Copper = 100% of the European NRV). Zinc is an essential trace element with over 10 EFSA-approved health claims, acting as a cofactor for over 300 enzymes and more than 1000 transcription factors in the human body. The inclusion of Copper in the formula is a decision based on scientific evidence: chronic supplementation with high doses of Zinc can induce Copper depletion through competitive mechanisms of intestinal absorption, making co-supplementation with Copper relevant to maintain Zn\/Cu balance. Each capsule provides 25 mg of elemental Zinc (250% of the European NRV of 10 mg) and 1 mg of elemental Copper (100% of the European NRV of 1 mg). 1 capsule per day. Vegan, gluten-free, GMO-free, allergen-free. Available in 30, 120, and 240 capsules.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eChelated zinc bisglycinate: the form with the highest bioavailability and best gastrointestinal tolerance:\u003c\/strong\u003e Zinc bisglycinate is a chelate formed by the binding of a Zinc ion (Zn2+) to two molecules of the amino acid glycine. This chelation gives Zinc pharmacokinetic properties far superior to simple inorganic forms: zinc bisglycinate is more soluble in the intestinal environment, more resistant to the formation of insoluble chelates with phytates and fibers (which dramatically reduce the absorption of inorganic zinc), and is absorbed through amino acid transporters in the intestinal epithelium that are different and independent of inorganic zinc transporters, avoiding competitive saturation. Comparative bioavailability studies document that zinc bisglycinate has 30 to 40% higher absorption than zinc sulfate (the reference form in clinical studies) and causes significantly less gastrointestinal discomfort (nausea, gastric irritation) than inorganic forms. Zinc bisglycinate provides ~30% elemental Zinc by salt weight, one of the highest mineral densities available.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eOver 10 EFSA-approved health claims for Zinc: a universal cofactor:\u003c\/strong\u003e Zinc has the highest number of EFSA-approved health claims of any trace element, covering virtually all physiological systems. Zinc is proven to contribute to: the protection of cells from oxidative damage, normal cognitive function, normal functioning of the immune system, maintenance of normal vision, maintenance of normal skin, maintenance of normal hair, maintenance of normal nails, normal DNA synthesis, normal fatty acid metabolism, normal macronutrient metabolism, normal protein synthesis, normal vitamin A metabolism, maintenance of normal bones, maintenance of normal testosterone levels in the blood, normal male reproductive function, and normal bone development in children. This breadth reflects Zinc's role as a cofactor for over 300 metalloproteins (enzymes that require Zinc for their catalytic activity) and over 1000 transcription factors that regulate gene expression in virtually all cell types in the body.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eImmune support: Zinc in the first and second lines of immune defense:\u003c\/strong\u003e Zinc is essential for the development and maturation of T lymphocytes (especially T-helper and cytotoxic T cells, central immune cells of adaptive immunity), for antibody production by B lymphocytes, and for the cytotoxic activity of NK cells (Natural Killer cells, innate immunity cells). Zinc depletion causes thymic atrophy (the organ where T lymphocytes mature), a sharp drop in thymulin levels (a thymic hormone that regulates zinc-dependent T lymphocyte maturation), and marked immune suppression that includes recurrent bacterial and viral infections. Intervention studies with Zinc supplementation in the elderly (where Zinc deficiency is prevalent) document a reduction in the incidence and duration of respiratory infections and an improvement in cellular immunity markers.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAntioxidant protection via zinc-copper superoxide dismutase (Cu\/Zn-SOD):\u003c\/strong\u003e Zinc, together with Copper, is an essential cofactor of the cytoplasmic superoxide dismutase enzyme (Cu\/Zn-SOD), one of the most important enzymatic antioxidants in the body, responsible for the dismutation of the superoxide radical (O2•⁻) into hydrogen peroxide (H2O2) which is subsequently eliminated by catalase and glutathione peroxidase. The activity of Cu\/Zn-SOD depends on the simultaneous availability of Zinc and Copper at their active sites, making co-supplementation of both minerals (as in this formula) especially relevant for maintaining enzymatic antioxidant activity.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSkin, hair and nail support: Zinc in keratinized structures:\u003c\/strong\u003e Zinc is selectively concentrated in tissues with high cell proliferation, including the skin (especially the epidermis and sebaceous glands), hair follicles, and nail matrix cells. At the molecular level, Zinc is a cofactor for RNA polymerase and multiple transcription factors that regulate the differentiation and proliferation of keratinocytes (the predominant cells of the epidermis and skin appendages). Clinical studies document that Zinc deficiency causes dermatitis, alopecia (hair loss), and leukonychia (white spots on nails), all reversible with Zinc supplementation. The dosage of 25 mg\/day is the dose typically used in clinical studies supporting dermatological health.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTestosterone and male reproductive health support:\u003c\/strong\u003e Zinc has a documented role in the synthesis and metabolism of androgens. 5-alpha-reductase (the enzyme that converts testosterone to dihydrotestosterone) is a zinc-dependent metalloprotein. Additionally, Zinc inhibits aromatase (the enzyme that converts testosterone to estradiol), reducing the peripheral conversion of testosterone to estrogens. Clinical studies, including that by Prasad et al. (1996) published in the journal Nutrition, document that Zinc supplementation in men with Zinc deficiency increases serum testosterone levels and improves sperm count and motility.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eInclusion of Copper (cupric gluconate, 1 mg = 100% NRV): prevention of zinc-induced copper depletion:\u003c\/strong\u003e Zinc and Copper compete for the same intestinal divalent metal transporter (DMT1, Divalent Metal Transporter 1), and chronic supplementation with high doses of Zinc (typically above 50 mg\/day for prolonged periods) can induce Copper depletion by saturating DMT1 and reducing intestinal Copper absorption. Given that Copper is equally essential for numerous physiological functions (collagen synthesis, neurological function, hematopoiesis, Cu\/Zn-SOD activity), Copper depletion is clinically relevant and can cause anemia and neuropathy. HSN includes 1 mg of Copper (= 100% of the European NRV of 1 mg) in the Zinc Bisglycinate formula, ensuring coverage of Copper needs and preventing depletion associated with Zinc use.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 capsule per day. For best absorption, preferably take on an empty stomach or between meals, as foods rich in phytates (whole grains, legumes) reduce Zinc absorption. In case of gastric sensitivity, take with a light meal.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTiming:\u003c\/strong\u003e Many users prefer to take Zinc at night before bed, as Zinc is naturally released by the body during sleep and nighttime supplementation maximizes availability during the period of recovery and tissue repair that occurs during deep sleep.\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705357103451,"sku":null,"price":12.64,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/1_522fa7b8-bb82-4466-96e4-d55b902ab5bf.png?v=1780699199","url":"https:\/\/brothers-club.com\/en\/products\/product_5b6e031d-4687-4c2d-8fd6-7814157011df","provider":"Brother's Club","version":"1.0","type":"link"}