{"product_id":"product_2f6548a6-5516-4559-bd2e-da3d5d16f034","title":"HSN - PEA \u0026 MAG | 120caps","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHSN's EssentialSeries PEA \u0026 Mag is a dietary supplement in vegetable capsules based on ultramicronized palmitoylethanolamide (PEA) of plant origin and Magnesium Citrate, developed to support natural inflammatory balance, neuropathic pain modulation, and nervous system health. PEA (Palmitoylethanolamide) is an endogenous lipid belonging to the family of fatty acid amides, produced by the body itself in response to inflammatory stimuli and tissue injury, functioning as part of the body's natural anti-inflammatory defense system. Advanced micronization (particle size of 0.8 to 6 µm) ensures significantly higher bioavailability than conventional non-micronized PEA, which has very limited absorption due to its lipid nature and low aqueous solubility. The effective daily dose of 1200 mg of PEA is complemented with 250 mg of Magnesium via Magnesium Citrate (one of the forms with the highest bioavailability), which contributes to the normal functioning of the nervous system and the maintenance of bones. PEA of plant origin (rare and exclusive), suitable for vegan diets. Allergen-free, gluten-free, GMO-free.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePEA: the endogenous lipid amide with a central role in the body's natural anti-inflammatory defense system:\u003c\/strong\u003e Palmitoylethanolamide (PEA) is an amide of palmitic acid (C16:0) with ethanolamine, belonging to the family of lipid endocannabinoids. It is synthesized on demand by body cells in response to injury, inflammation, and cellular stress stimuli, functioning as an endogenous lipid modulator of the immune and nervous systems. PEA acts primarily as an agonist of PPAR-α (Peroxisome Proliferator-Activated Receptor alpha) receptors, which are nuclear transcription factors with a central role in modulating the expression of pro-inflammatory genes, and as a modulator of mast cells and microglia (the immune cells of the central nervous system), reducing the release of pro-inflammatory and pro-nociceptive mediators that amplify pain and chronic inflammation. This mechanism of action through PPAR-α distinguishes PEA from conventional NSAIDs (which inhibit COX-1 and COX-2) and cannabinoids (which act on CB1 and CB2 receptors), giving it an exceptional safety and tolerability profile without the gastrointestinal, cardiovascular, or psychoactive side effects associated with these other approaches.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eUltramicronization for maximum bioavailability: particle size of 0.8 to 6 µm:\u003c\/strong\u003e PEA is a lipid molecule with a high octanol\/water partition coefficient (high logP) and low aqueous solubility, which results in very variable and limited gastrointestinal absorption when administered in conventional crystalline form. Ultramicronization, which reduces particle size to 0.8 to 6 µm (micrometers), dramatically increases the contact surface with gastrointestinal fluid, improving effective solubility and intestinal absorption rate. Pharmacokinetic studies show that ultramicronized PEA has significantly higher plasma bioavailability than conventional PEA at the same dose, making the micronized form much more effective per gram of product ingested. The dose of 1200 mg\/day of ultramicronized PEA from HSN is the dose used in clinical studies that document the most consistent effects in modulating neuropathic and inflammatory pain.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGrowing evidence base: more than 70 to 80 clinical studies published per year since 2012:\u003c\/strong\u003e PEA was discovered in 1957 and identified in mammalian tissues in 1965, but the explosion of scientific interest has occurred in recent decades. Since 2012, 70 to 80 clinical studies on PEA are published annually, making it one of the fastest-growing compounds in research in the fields of nutrition and neuroscience. Areas with the strongest evidence base include: chronic neuropathic pain (including diabetic neuropathy, carpal tunnel syndrome, and post-herpetic neuralgia), chronic inflammatory pain (including osteoarthritis and fibromyalgia), neurological and neurodegenerative conditions, and support for muscle and joint recovery in athletes. Published meta-analyses document consistent reductions in pain scores across multiple chronic pain models with PEA doses between 300 and 1200 mg\/day.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eModulation of neuropathic and inflammatory pain without significant adverse effects:\u003c\/strong\u003e PEA has an exceptional safety profile, with no significant adverse effects documented in studies of continuous use for up to 12 months, no potential for dependence, no known significant pharmacological interactions, and none of the gastrointestinal risks of NSAIDs or the cardiovascular risks of corticosteroids. This safety makes PEA especially relevant for populations vulnerable to the adverse effects of conventional analgesics, including older adults with kidney or gastrointestinal disease, athletes who wish to avoid the health risks of chronic NSAID use, and people with neuropathic pain where NSAIDs are ineffective.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSupport for joint and muscle recovery in athletes:\u003c\/strong\u003e Intensive use of muscles and joints in high-intensity training causes localized micro-inflammation, which is the normal physiological sign of the adaptation and recovery process. PEA, through its modulating action on mast cells and the local inflammatory response, can contribute to a more efficient resolution of this post-exercise inflammatory process, reducing recovery time and joint and muscle discomfort between training sessions. Its use is especially relevant for athletes with chronic low-grade joint inflammation associated with overuse or high-intensity training.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePlant-sourced PEA: vegan, exclusive, and more sustainable:\u003c\/strong\u003e PEA is typically extracted from animal sources (egg yolk, animal tissues), with plant-sourced PEA being rare and more complex and expensive to produce. HSN chooses to use exclusively plant-derived PEA, making the product suitable for vegan and vegetarian diets and for all users who, for ethical, religious, or preference reasons, avoid animal products. This choice differentiates HSN's PEA \u0026 Mag from most PEA supplements available on the market.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMagnesium Citrate for synergistic nervous system support:\u003c\/strong\u003e Magnesium (via Magnesium Citrate, one of the forms with the highest bioavailability) complements the action of PEA in supporting the central and peripheral nervous system. As recognized by the EFSA, Magnesium has been shown to contribute to the normal functioning of the nervous system, the reduction of tiredness and fatigue, normal muscle function, and the maintenance of normal bones. Magnesium also plays a specific role in modulating pain transmission at the CNS level, acting as a natural antagonist of the NMDA (N-methyl-D-aspartate) receptor, the main glutamatergic receptor involved in central sensitization of chronic pain. This action complements and potentiates the anti-nociceptive mechanisms of PEA, justifying the synergistic combination of the two molecules in a unique formula.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take the dose indicated on the package (typically 2 to 4 capsules per day) with meals. Taking it with fat-containing foods improves PEA absorption, as its lipid nature benefits from the presence of dietary fat in the intestine for incorporation into absorption micelles.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDuration of treatment:\u003c\/strong\u003e The effects of PEA are cumulative and typically require 4 to 12 weeks of continuous use for clinically noticeable results in chronic pain conditions. For sports recovery support, effects may be noticeable more quickly (1 to 4 weeks).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSynergistic combinations:\u003c\/strong\u003e For more comprehensive joint support, combine with HSN's Joint Health Collagen Powder (which includes Chondroitin, Glucosamine, MSM, and Boswellia) or with Omega-3 (which has complementary anti-inflammatory properties through the resolvin and protectin pathway).\u003c\/p\u003e","brand":"HSN","offers":[{"title":"Default Title","offer_id":52705356054875,"sku":null,"price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/HSN-PEA_MAG_MICRONIZEDPALMITOYLTANOLAMIDE_MAGNESIUM.webp?v=1777501805","url":"https:\/\/brothers-club.com\/en\/products\/product_2f6548a6-5516-4559-bd2e-da3d5d16f034","provider":"Brother's Club","version":"1.0","type":"link"}