{"product_id":"product_1728fd37-0b94-4487-8b7e-795e0a77cb5e","title":"Life Pro - GLUTATHIONE | 60 capsules","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLife Pro Nutrition's Reduced Glutathione is a food supplement in vegetable capsules (VCAPS) based on L-glutathione in its reduced form, the biologically active form of the human body's master antioxidant. Each capsule provides 250 mg of pure reduced L-glutathione. Glutathione (GSH, gamma-L-glutamyl-L-cysteinyl-glycine) is a tripeptide composed of three amino acids: L-cysteine, glycine, and glutamic acid (glutamate), and is considered the body's main endogenous antioxidant, present in all cells, playing a central role in protecting against oxidative stress, liver detoxification, immune system regulation, and maintaining other antioxidants (Vitamin C, Vitamin E, CoQ10, alpha-lipoic acid) in their active forms. Dosage: 1 capsule per day. 60 capsules per pack (60 days). Vegan, lactose-free, gluten-free.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe \"master antioxidant\": glutathione as the central hub of intracellular antioxidant defense:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eReduced glutathione (GSH) is the most abundant intracellular antioxidant in the human body, present in concentrations of 1 to 10 mmol\/L in the cytosol of cells, with the highest concentrations in the liver (where it exerts its most intense detoxifying functions), erythrocytes, lungs, and kidneys. Unlike exogenous antioxidants consumed through diet (Vitamin C, polyphenols, carotenoids), glutathione is synthesized endogenously by the cells themselves, making it the intracellular antioxidant system par excellence. What distinguishes it from other antioxidants is its position as a central hub in the antioxidant system: in addition to directly neutralizing free radicals and reactive oxygen species (ROS), GSH is a cofactor for glutathione peroxidases (GPx), the enzymes that eliminate lipid peroxides and hydrogen peroxide from tissues, and is the substrate for glutathione reductase, the enzyme that regenerates oxidized Vitamin C (dehydroascorbic acid) back to its active form (ascorbic acid) and maintains Vitamin E in its reduced and active form. In this way, glutathione not only acts as a direct antioxidant but also enhances and sustains the antioxidant action of all other antioxidants in the body: without sufficient glutathione, Vitamin C, Vitamin E, CoQ10, and alpha-lipoic acid cannot be regenerated to their active forms after neutralizing free radicals, becoming less effective.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eReduced form (GSH) vs. oxidized form (GSSG): only the reduced form is biologically active:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eGlutathione exists in two interconvertible forms: the reduced form (GSH, with the free and reactive thiol group -SH) and the oxidized form (GSSG, glutathione disulfide, formed by two GSH residues linked by a disulfide bridge). Only the reduced form (GSH) is biologically active as an antioxidant: it is the thiol group (-SH) of cysteine that donates electrons to neutralize free radicals and reactive oxygen species. The intracellular GSH\/GSSG ratio is a sensitive marker of the cell's redox state: in healthy cells, more than 98% of total glutathione is in the reduced form (GSH), while in situations of high oxidative stress (such as intense physical exercise, chronic inflammation, or in disease contexts), the proportion of GSSG increases. Supplementation with glutathione in its reduced form ensures that the biologically active form is delivered directly to the body, without the need for prior enzymatic conversion.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLiver detoxification: glutathione as the main agent for conjugation and elimination of xenobiotics:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe liver is the organ with the highest concentration of glutathione in the body and the main site where it performs its detoxifying functions. Liver detoxification occurs in two phases: phase I (oxidation of xenobiotics by cytochrome P450 enzymes, which often generates metabolites that are more reactive and potentially more toxic than the original compound) and phase II (conjugation of phase I metabolites with endogenous molecules such as glucuronate, sulfate, or glutathione to make them water-soluble and facilitate their excretion in bile or urine). Glutathione is one of the main phase II conjugating agents: glutathione-S-transferase (GST) catalyzes the covalent binding of GSH to a wide variety of electrophilic metabolites (including drug metabolites, pesticides, organic solvents, lipid peroxidation products) forming glutathione conjugates that are subsequently exported from the cell and eliminated from the body. This detoxifying function is particularly relevant for drug metabolism, for the elimination of heavy metals (such as mercury, lead, and cadmium, which form conjugates with glutathione), and for the elimination of carcinogenic compounds.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eImmune system: glutathione in lymphocyte proliferation and immune response regulation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eGlutathione plays an essential role in the functioning of the immune system, especially in the function of T lymphocytes and NK (Natural Killer) cells. Cytotoxic T lymphocytes and NK cells require high intracellular levels of GSH to proliferate adequately after antigenic stimulation and to exert their cytotoxic activity against virus-infected cells or tumor cells. GSH is necessary for the synthesis of leukotrienes (pro-inflammatory lipid mediators via 5-lipoxygenase, whose co-factor is GSH), for the production of acute phase proteins and regulatory cytokines, and for the regulation of programmed cell death (apoptosis) of lymphocytes after the immune response. Studies document that glutathione deficiency is associated with impaired immune response and increased susceptibility to viral and bacterial infections.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe decline of glutathione with aging and factors that reduce endogenous levels:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eGlutathione levels progressively decrease with aging: studies document that GSH levels in blood and tissues decrease by 30 to 40% between 30 and 70 years of age, contributing to the increase in oxidative stress associated with aging. In addition to aging, multiple factors reduce endogenous glutathione synthesis or increase its consumption: high-intensity physical exercise (which increases ROS production and GSH consumption in mitochondria), chronic stress (which activates the HPA axis and increases free radical production), exposure to pollutants, pesticides and heavy metals, alcohol consumption (which depletes hepatic GSH), poor diet (cysteine deficiency, the limiting amino acid for GSH synthesis), and various chronic diseases (diabetes, cardiovascular diseases, autoimmune diseases). Supplementation with reduced glutathione can compensate for these losses, especially in contexts of high oxidative stress.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSkin health and anti-aging properties: the mechanism of skin brightening and protection:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eGlutathione has been increasingly studied for its role in skin health. Its antioxidant activity protects keratinocytes and dermal fibroblasts against oxidative damage caused by UV radiation, pollution, and intrinsic aging processes. Glutathione also modulates melanin synthesis (the skin pigment): studies document that GSH inhibits tyrosinase (the central enzyme in the melanin synthesis pathway), shifting the production from eumelanin (dark, brownish-black pigment) to pheomelanin (light, yellowish-red pigment), which results in a more uniform and luminous skin tone with continued use. This property has driven interest in oral glutathione as a \"skin brightening\" and anti-aging supplement, in addition to its broader systemic benefits.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take 1 capsule per day, preferably on an empty stomach or with a light meal (to maximize absorption, as the presence of food may compete with intestinal absorption of glutathione). The benefits are progressive and depend on continuous regular use.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSynergy with other supplements:\u003c\/strong\u003e Glutathione enhances and is enhanced by Vitamin C (which regenerates it from the oxidized to the reduced form), alpha-lipoic acid (which recycles oxidized GSH and is itself a potent mitochondrial antioxidant), N-acetylcysteine\/NAC (which increases endogenous glutathione synthesis by providing cysteine, the limiting amino acid), Vitamin E, and CoQ10 (whose active forms are maintained by GSH). The combination with NAC is particularly synergistic since NAC increases endogenous GSH production while the glutathione supplement directly provides the active form.\u003c\/p\u003e","brand":"Life Pro","offers":[{"title":"Default Title","offer_id":52705358119259,"sku":null,"price":24.9,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/LifePro-HealthyGlutation60Vegancaps.png?v=1776592981","url":"https:\/\/brothers-club.com\/en\/products\/product_1728fd37-0b94-4487-8b7e-795e0a77cb5e","provider":"Brother's Club","version":"1.0","type":"link"}