{"product_id":"marvelous-nutrition-beta-alanina","title":"Marvelous Nutrition - Beta Alanine","description":"\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eMarvelous Nutrition's Beta-Alanine is a powdered supplement of \u003cstrong\u003e100% pure beta-alanine, without additives\u003c\/strong\u003e, formulated with a single ingredient in its cleanest form. Beta-alanine is a non-essential and non-proteogenic amino acid (not incorporated into structural proteins, unlike alpha-alanine) that acts as the limiting precursor for carnosine synthesis in skeletal muscle — the main intracellular buffer that neutralises the acidity accumulated during high-intensity exercise. Beta-alanine supplementation is among the sports supplements with the strongest evidence base for improving muscle endurance in high-intensity efforts lasting between 1 and 4 minutes, being one of the few supplements recognised by the ISSN (International Society of Sports Nutrition) as an ergogenic aid with Level A evidence. 3g\/day, 30 minutes before training. Vegan. No additives.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe central mechanism: beta-alanine → carnosine → H⁺ buffering → delayed muscle fatigue:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eBeta-alanine has a specific and biochemically well-characterised mechanism of action. In skeletal muscle, beta-alanine combines with L-histidine via the enzyme \u003cstrong\u003ecarnosine synthase\u003c\/strong\u003e to form \u003cstrong\u003ecarnosine\u003c\/strong\u003e (beta-alanyl-L-histidine), a dipeptide accumulated in very high concentrations in type II muscle fibers (fast-twitch fibers, the most recruited in high-intensity exercise). Muscle carnosine has multiple functions, but the most relevant for sports performance is its role as an \u003cstrong\u003eintracellular H⁺ ion buffer\u003c\/strong\u003e: during high-intensity exercise, anaerobic glycolysis produces lactate and H⁺ in large quantities, causing intracellular acidosis (a drop in muscle pH) that inhibits key enzymes like phosphofructokinase (PFK) and myosin ATPase, reducing the rate of ATP production and muscle contraction force — this is the primary physiological mechanism of muscle fatigue in high-intensity effort. Carnosine, with a pKa of ~6.83 (very close to physiological muscle pH during exercise), absorbs the H⁺ produced by anaerobic glycolysis, buffering acidosis and delaying the pH drop that causes fatigue. The reason for supplementing with beta-alanine instead of carnosine directly is that oral carnosine is rapidly hydrolysed by plasma carnosinases before reaching the muscle, whereas beta-alanine survives circulation and is taken up by myocytes for local carnosine synthesis.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBeta-alanine as a limiting precursor: why histidine is not the limiting factor:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eMuscle carnosine synthesis is limited by the availability of beta-alanine, not L-histidine. This is because the intramuscular concentration of free L-histidine is generally sufficient to saturate carnosine synthase, while free beta-alanine in the muscle is usually very low (the muscle synthesises very little beta-alanine endogenously, relying mainly on dietary sources — meat, fish). Oral beta-alanine supplementation substantially increases the intracellular availability of this amino acid, shifting the carnosine synthase equilibrium towards carnosine synthesis and progressively increasing muscle carnosine content over weeks to months of supplementation. The foundational study by Harris et al. (2006), published in Amino Acids, documented that supplementation with 4-6 g\/day of beta-alanine for 4 weeks increased muscle carnosine content by 40 to 60% in the vastus lateralis.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eClinical evidence: the ISSN position and meta-analyses:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eBeta-alanine is one of the most well-studied sports supplements in randomised clinical trials. The meta-analysis by Hobson et al. (2012), published in Amino Acids with data from 15 studies, documented that beta-alanine supplementation significantly improved performance in exercises lasting 1 to 4 minutes (Cohen's d = 0.374), with a particularly pronounced effect in efforts of 60 to 240 seconds. The ISSN Position Stand on beta-alanine (Trexler et al., 2015) classified beta-alanine as \u003cstrong\u003eLevel A evidence\u003c\/strong\u003e (the highest classification) for improving performance in high-intensity exercises lasting between 1 and 4 minutes, and for increasing muscle carnosine content with chronic supplementation. Sports and modalities with the greatest documented benefit include: swimming (100 to 400m events), cycling (2 to 4-minute time trials), rowing, boxing, MMA, CrossFit, weight training (8 to 20 reps at high intensity) and football (repeated sprints).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e100% pure formula without additives: the advantage of standalone beta-alanine:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eMarvelous Nutrition's choice of a single-ingredient formulation without any additives (no flavourings, colourings, sweeteners, anti-caking agents or fillers) has several practical advantages for the user. It allows completely flexible and personalised dosing (from 1.6 g to 6.4 g\/day depending on the chosen protocol) without being limited to the predefined dose of a combined pre-workout. It also allows free combination with any other supplement (creatine, citrulline, caffeine, protein) without unwanted accumulation of other ingredients. And it guarantees that the user is taking exclusively high-quality beta-alanine, without confounding variables from other active ingredients.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eParesthesia (tingling): the benign side effect and how to minimise it:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe most common and well-known side effect of beta-alanine is \u003cstrong\u003eparesthesia\u003c\/strong\u003e (a tingling, prickling, or flushing sensation on the skin, especially on the face, neck, hands, and ears), which occurs 15 to 20 minutes after ingesting doses ≥800 mg and lasts 60 to 90 minutes. Paresthesia is completely benign (there is no evidence of any tissue or neurological damage) and results from the activation of histamine receptors and MrgprD receptors (Mas-related G-protein coupled receptor D) in cutaneous sensory neurons by circulating beta-alanine. To minimise paresthesia: divide the daily dose into multiple intakes of ≤800 mg throughout the day; take with meals (which slows absorption and reduces plasma peak); or use sustained-release formulations. With continued use, tolerance to paresthesia progressively develops in most users.\u003c\/p\u003e\n\u003ch2 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUses\u003c\/h2\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Dissolve 3g in 100 to 200 ml of water, 30 minutes before training. To minimise paresthesia, the dose can be divided into 2 intakes of 1.5g throughout the day. For the maximum loading protocol (most studied), use 3.2 to 6.4 g\/day divided into doses of 800 mg to 1.6 g, distributed throughout the day with meals, for 4 to 12 weeks. The benefits of beta-alanine are cumulative and depend on the progressive increase in muscle carnosine content: effects are observable from the 3rd to 4th week of regular supplementation.\u003c\/p\u003e","brand":"Marvelous Nutrition","offers":[{"title":"Default Title","offer_id":52848513581403,"sku":null,"price":23.9,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/MarvelousNutrition-BetaAlanine.webp?v=1776792071","url":"https:\/\/brothers-club.com\/en\/products\/marvelous-nutrition-beta-alanina","provider":"Brother's Club","version":"1.0","type":"link"}