About the Product
Hyaluronic Acid 150mg by HSN EssentialSeries is a high molecular weight Hyaluronic Acid supplement in HPMC vegetable capsules, part of the HSN EssentialSeries Beauty line, with 150mg of base Hyaluronic Acid per capsule (in the stable form of vegetable fermentation Sodium Hyaluronate, 100% non-GMO), supplemented with Vitamin C, Biotin, and Manganese Citrate to support collagen synthesis and skin, hair, and joint health. HSN specifically uses the high molecular weight form — the form with the best results in clinical studies on dermal hydration and joint support — and transparently states that the indicated 150mg corresponds to the base hyaluronic acid (not the sodium salt complex, which would weigh more). 1 capsule/day. Vegan. Gluten-free. Non-GMO. 60 or 120 capsules.
Ingredients: Sodium Hyaluronate (vegetable fermentation, ~95% base hyaluronic acid) + Vitamin C (ascorbic acid) + Biotin (D-biotin) + Manganese Citrate + Vegetable capsule (HPMC).
Benefits
Hyaluronic Acid: the glycosaminoglycan that maintains hydration in connective and joint tissues:
Hyaluronic Acid (HA, hyaluronan) is a long-chain anionic polysaccharide composed of repeating units of D-glucuronic acid and N-acetyl-D-glucosamine, ubiquitously distributed throughout all connective, epithelial, and nervous tissues in the body. A 70kg person contains approximately 15g of hyaluronic acid in the body, of which ~5g are degraded and resynthesized daily — making HA one of the most dynamic polymers in the human body. The highest concentrations of HA are found in the synovial fluid of joints (where it provides viscosity and lubrication that protects cartilaginous surfaces from friction), in the skin (where it retains water in the dermis and provides turgor and elasticity to the tissue), in the vitreous humor of the eye, and in the umbilical cord. HA's water retention capacity is extraordinary — up to 1000ml of water per gram of dry HA — making it the primary hydrating agent of connective tissues.
High molecular weight: the form that HSN advocates as the most effective for nutricosmetics:
Hyaluronic Acid is classified into multiple molecular weight ranges: high (>1,000 kDa), low (<100 kDa), extra-low, super-low, and ultra-low. HSN explicitly positions high molecular weight as the best option for oral supplementation with nutricosmetic goals (dermal hydration, skin elasticity) and joint health, based on the Dalton studies conducted with its ingredient. High molecular weight hyaluronic acid has a greater water retention capacity per molecule (more repeating units = more water binding sites) and is present in higher concentrations in synovial fluid and young dermis — making it the most physiologically relevant for restoring levels that decline with age. Some more recent studies suggest that low molecular weight fragments have greater oral bioavailability, but HSN opts for high molecular weight based on established clinical efficacy studies.
Sodium Hyaluronate: the stable, 100% non-GMO vegetable fermentation form:
Sodium Hyaluronate (the sodium salt of HA) is the most stable form of hyaluronic acid for supplement formulation — more resistant to degradation during processing and storage than base hyaluronic acid. HSN's HA is produced by vegetable fermentation (using bacterial strains of Streptococcus zooepidemicus grown on vegetable substrates, without animal or human origin) and certified as 100% GMO-free — unlike some HA on the market produced in cultures with transgenic ingredients. HSN declares that the 150mg per capsule corresponds to base hyaluronic acid (subtracting the sodium from the salt), not the total sodium hyaluronate — a transparency practice that allows direct comparison of the base HA dose with other supplements on the market.
Vitamin C: the collagen synthesis cofactor that maximizes the effect of hyaluronic acid:
As already described in multiple products in this session, Vitamin C is the essential cofactor for prolyl and lysyl hydroxylases — the enzymes that synthesize collagen. The inclusion of Vitamin C in Hyaluronic Acid 150mg is especially relevant because HA and collagen are the two most important macromolecules in the dermal extracellular matrix and articular synovial fluid, and both depend on an appropriate synthesis environment: HA provides matrix hydration and volume, and collagen provides the supporting structure — and Vitamin C is essential for the synthesis of collagen that "anchors" HA in the dermis. EFSA has approved the claim: "Vitamin C contributes to normal collagen formation for the normal function of the skin."
Biotin (D-Biotin) + Manganese Citrate: support for hair and proteoglycan synthesis:
D-Biotin (the biologically active form of biotin) is added to the formula for its documented relationship with hair health (cofactor of carboxylases that support hair keratinization) and nails — complementing HA's effect on skin hydration with direct support for hair and nails. Manganese Citrate (a bioavailable form of manganese) is a cofactor for glycosyltransferases — the enzymes that synthesize glycosaminoglycans (including hyaluronic acid itself) — making manganese an essential nutrient for the endogenous synthesis of HA by skin and joint cells.
150mg of base HA per capsule: the effective dose within the range of clinical studies:
The dose of 150mg of Hyaluronic Acid per capsule is one of the highest doses available on the market for HA supplements in capsules — most competitors use 50 to 100mg/capsule. The review by Gupta et al. (2019), published in Frontiers in Veterinary Science, documented that oral HA doses of 80 to 200mg/day produce measurable effects on skin hydration and joint comfort. HSN's 150mg dose is at the center of this efficacy window.
Dual application — skin and joints — hyaluronic acid as a universal supplement:
HA is one of the few ingredients with solid clinical evidence in two seemingly distinct domains: nutricosmetics (improvement of dermal hydration and elasticity, wrinkle reduction) and joint health (synovial fluid support, reduction of joint friction in osteoarthritis). For athletes, the dual application is especially relevant: intensive training causes mechanical stress on joints (depleting HA from synovial fluid) and oxidative stress on the skin (accelerating skin aging). HSN's Hyaluronic Acid 150mg covers both needs in a single daily capsule.
Uses
Recommended dose: Take 1 capsule per day, preferably with a meal. Can be taken at any time of day. 60 capsules = 60 days / 120 capsules = 120 days. For visible effects on the skin, HA requires consistent use for at least 4 to 8 weeks — effects on dermal hydration and elasticity develop gradually with the accumulation of HA in tissues.
