{"title":"Nutrex Research","description":"","products":[{"product_id":"product_836accc0-71ae-4451-8d5e-e9bb32c6f63e","title":"Nutrex - Lipo 6 Black Ultra Concentrate | 60 capsules","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 Black Ultra Concentrate is the \u003cstrong\u003eultra-concentrated and maximum potency\u003c\/strong\u003e version of Lipo-6 Black — Nutrex's best-selling fat burner — formulated for those who already have an established tolerance to stimulants and want the most intense thermogenic effect available in a single dose. With \u003cstrong\u003ejust 1 Liqui-Cap per serving\u003c\/strong\u003e, Lipo-6 Black UC delivers a thermogenic blend of 295 to 315mg of 5 ultra-concentrated active ingredients in a pre-dissolved liquid format for ultra-fast absorption: \u003cstrong\u003eCaffeine Anhydrous (200mg), Theobromine Anhydrous, Advantra Z® (Citrus aurantium 50% p-Synephrine), Yohimbine HCl, and Rauwolscine (Rauwolfia vomitoria)\u003c\/strong\u003e. The \"one pill only\" philosophy is the distinguishing mark of UC: a formula so potent that you should never exceed 1 capsule per dose, never more than 2 capsules per day. Vegan (HPMC capsule). 60 capsules (30 doses of 2 capsules\/day = 30 days of use).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIngredients per capsule:\u003c\/strong\u003e Ultra Concentrated Weight Loss Support Complex ~295-315mg (proprietary blend): Caffeine Anhydrous + Theobromine Anhydrous + Advantra Z® Citrus aurantium (50% p-Synephrine) + Yohimbine HCl + Rauwolscine (Rauwolfia vomitoria, 90% Rauwolscine HCl). Other ingredients: Glycerin + Vegetable Cellulose (HPMC capsule) + Purified Water + Polysorbate 80 + FD\u0026amp;C Colorants.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLipo-6 Black vs. Lipo-6 Black Ultra Concentrate: the difference that defines two distinct products:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLipo-6 Black\u003c\/strong\u003e (already described in this session) and \u003cstrong\u003eLipo-6 Black Ultra Concentrate\u003c\/strong\u003e are two Nutrex products with distinct philosophies despite their similar names. The standard Lipo-6 Black has 9 active ingredients (caffeine, theobromine, L-tyrosine, choline, grains of paradise, yohimbine, rauwolscine, huperzine-A, BioPerine), 3 capsules per serving, 220mg of total caffeine per serving — a comprehensive formula with cognitive components (L-tyrosine, choline, huperzine-A) and diverse thermogenic agents (grains of paradise, BioPerine). The \u003cstrong\u003eUltra Concentrate\u003c\/strong\u003e is deliberately simpler and more concentrated: 5 core ingredients with an exclusive focus on maximum thermogenesis and lipolysis, 200mg of caffeine in a single small capsule, with no additional cognitive components. The practical difference is that UC is the \"one pill wonder\" — 1 capsule so potent that you cannot take more than one per dose — while the standard Lipo-6 Black uses 3 capsules per dose to distribute the effect. For advanced athletes who have already used the standard Lipo-6 Black and want to scale up the potency, or for those who prefer the convenience of 1 capsule instead of 3, UC is the direct upgrade.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e200mg of caffeine per capsule: the high-efficacy dose in a single Liqui-Cap:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWith \u003cstrong\u003e200mg of anhydrous caffeine per capsule\u003c\/strong\u003e (equivalent to approximately 2 strong cups of coffee), Lipo-6 Black UC has the highest caffeine concentration per dosage unit in the Nutrex portfolio. The \u003cstrong\u003eLiqui-Cap\u003c\/strong\u003e technology (already described in the Lipo-6 Black section) pre-dissolves caffeine and other ingredients in a liquid medium within the capsule, resulting in a significantly faster onset of effect than tablets or powder capsules: 10 to 20 minutes vs. 30 to 45 minutes for solid forms. For athletes who need a rapid onset before training, this technology is a relevant practical differentiator.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAnhydrous Theobromine: the long-lasting xanthine that sustains the thermogenic effect:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the standard Lipo-6 Black section, \u003cstrong\u003etheobromine\u003c\/strong\u003e (3,7-dimethylxanthine) has a half-life of 7 to 12 hours — much longer than caffeine (3 to 5 hours) — and provides a more prolonged and gentler thermogenic and vasodilating effect. In the context of UC, the combination of caffeine (rapid onset, intense and medium-duration effect) + theobromine (slower onset, gentler and long-duration effect) creates the same characteristic biphasic energy curve of Lipo-6 Black: an initial peak with caffeine, sustained for hours with theobromine, without the abrupt crash typical of isolated caffeine.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAdvantra Z® (Citrus aurantium 50% p-Synephrine): the most concentrated and studied p-synephrine on the market:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAdvantra Z®\u003c\/strong\u003e (a registered trademark of Nutratech Inc.) is the most clinically studied Citrus aurantium extract standardized to \u003cstrong\u003e50% p-synephrine\u003c\/strong\u003e available on the market — with over 30 published clinical studies documenting its thermogenic and body composition support effects. The standardization to 50% p-synephrine is exceptionally high (most market extracts use 6 to 30% synephrine), meaning that even small doses of Advantra Z® provide a significant active dose of p-synephrine per capsule. As described in multiple previous products in this session, p-synephrine activates the β3-adrenergic receptors of adipocytes (stimulating lipolysis and thermogenesis via UCP1) without the marked cardiovascular effects of ephedrine (which also activates α and β1\/β2 receptors with a more pronounced hypertensive and tachycardic effect). Advantra Z® has the approval of multiple regulatory agencies as a safe ingredient in thermogenic supplements, being the reference extract for synephrine studies in scientific literature.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eYohimbine HCl + Rauwolscine (90% alpha-yohimbine): the dual-potency α2 unlock:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs extensively described in the \u003cstrong\u003eLipo-6 Black\u003c\/strong\u003e standard section, the combination of \u003cstrong\u003eYohimbine HCl + Rauwolscine\u003c\/strong\u003e (alpha-yohimbine from Rauwolfia vomitoria) is the most potent legal stack available in supplements for mobilizing stubborn subcutaneous fat via blocking α2-adrenergic receptors. In UC, these two ingredients are pre-dissolved in the Liqui-Cap along with caffeine and synephrine — which creates an intense pharmacological synergy:\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eCaffeine and synephrine increase the release of norepinephrine and adrenaline by the sympathetic nervous system (via phosphodiesterase inhibition and activation of β-adrenergic receptors). Yohimbine and rauwolscine block the α2 receptors of adipocytes (which normally \"brake\" lipolysis when activated by norepinephrine). With α2 blocked and β3 activated (by synephrine), the norepinephrine and adrenaline stimulated by caffeine maximally activate hormone-sensitive lipase (HSL) in adipocytes — resulting in the most intense lipolysis possible with natural ingredients. \u003cstrong\u003eRauwolscine\u003c\/strong\u003e (90% alpha-yohimbine) has a higher affinity for the α2 receptor than conventional yohimbine, amplifying the α2 blocking effect with a lower dose. The synergy of the 5 ingredients in UC creates the most potent thermogenic and lipolytic stack per capsule available in the Nutrex portfolio.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe \"One Pill Only\" philosophy: because ultra-concentration is the UC's raison d'être:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe central positioning of Lipo-6 Black Ultra Concentrate is its formula, so concentrated that Nutrex imposes the limit of \u003cstrong\u003eNEVER exceeding 1 capsule per dose\u003c\/strong\u003e and \u003cstrong\u003eNEVER taking more than 2 capsules within 24 hours\u003c\/strong\u003e — not as a suggestion, but as a mandatory safety warning. This differentiates UC from conventional fat burners where 2 to 4 capsules are taken per dose: in UC, a single Liqui-Cap delivers all the necessary potency. For advanced athletes with high stimulant tolerance, this maximum concentration may be exactly what was missing to bypass the tolerance developed with multiple-dose fat burners. For beginners or athletes with low caffeine tolerance, UC is not suitable — the standard Lipo-6 Black (with 220mg of caffeine in 3 capsules and with more cognitive soothing ingredients) is the safer entry into the Nutrex portfolio.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take \u003cstrong\u003e1 capsule in the morning\u003c\/strong\u003e and \u003cstrong\u003e1 capsule in the afternoon\u003c\/strong\u003e, at least 30 minutes before a meal. \u003cstrong\u003eNEVER exceed 1 capsule per dose. NEVER take more than 2 capsules in any 24-hour period.\u003c\/strong\u003e Do not take within 6 hours before bedtime. To assess tolerance, start with 1 capsule only in the morning for the first 3 days before progressing to 2 capsules\/day. Use in cycles: maximum 60 days of continuous use followed by a 15-day break.\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52705354416475,"sku":null,"price":24.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/Nutrex-Lipo6BlackUltraConcentrate.png?v=1777586325"},{"product_id":"product_105c2125-25c5-41a6-a41e-2bc4a92f68d8","title":"Nutrex - Lipo 6 Intense | 60caps","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 Black Intense is the \u003cstrong\u003emost potent and advanced\u003c\/strong\u003e version of the entire Lipo-6 Black line — positioned above the Ultra Concentrate as the \"elite level\" fat burner for users with high stimulant tolerance who seek the most intense thermogenic available. The formula expands on the UC's stack by adding \u003cstrong\u003eGBBGO®\u003c\/strong\u003e (Gamma-Butyrobetaine Hydrochloride, the \"super precursor\" of L-Carnitine with a potent independent thermogenic effect) and increases the caffeine dose to \u003cstrong\u003e~250mg per capsule\u003c\/strong\u003e (vs. 200mg in the UC). Ultra Concentrated Fat Loss Support Complex of \u003cstrong\u003e315.1mg per capsule\u003c\/strong\u003e: Anhydrous Caffeine + Anhydrous Theobromine + AdipoSyn™ Citrus aurantium (50% p-Synephrine) + GBBGO® + Yohimbine HCl + Rauwolscine. Liqui-Cap technology for ultra-fast absorption. 1 capsule\/dose, 2x\/day. 60 capsules. Vegan (HPMC capsule).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIngredients per capsule (proprietary blend 315.1mg):\u003c\/strong\u003e Anhydrous Caffeine + Anhydrous Theobromine + AdipoSyn™ (Citrus aurantium, 50% p-Synephrine) + GBBGO® (Gamma-Butyrobetaine Hydrochloride) + Yohimbine HCl + Rauwolfia vomitoria Extract (90% Rauwolscine HCl). Other ingredients: Glycerin + Vegetable Cellulose (HPMC capsule) + Purified Water + Polysorbate 80 + FD\u0026C Colorants.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe Lipo-6 Black hierarchy: Standard → Ultra Concentrate → Intense:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex's Lipo-6 Black portfolio follows a clear potency hierarchy. The standard \u003cstrong\u003eLipo-6 Black\u003c\/strong\u003e (220mg caffeine, 3 capsules\/dose, 9 ingredients with cognitive components) is the entry point into the portfolio. \u003cstrong\u003eLipo-6 Black Ultra Concentrate\u003c\/strong\u003e (200mg caffeine, 1 capsule\/dose, 5 ultra-concentrated ingredients) is the step-up in concentration. \u003cstrong\u003eLipo-6 Black Intense\u003c\/strong\u003e (250mg caffeine, 1 capsule\/dose, 6 ingredients with additional GBBGO®) is the top of the line — the version for advanced users who have already maximized the effects of UC and want more thermogenic power. The core difference between UC and Intense is the addition of \u003cstrong\u003eGBBGO®\u003c\/strong\u003e and the increase from 200mg to ~250mg of caffeine, which significantly boosts thermogenic intensity and total lipolytic effect.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGBBGO® (Gamma-Butyrobetaine Hydrochloride): the \"super carnitine\" and the most potent thermogenesis inducer in the formula:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGBBGO®\u003c\/strong\u003e (Gamma-Butyrobetaine Hydrochloride, GBB) is the exclusive differentiating ingredient in Lipo-6 Black Intense that is not present in standard UC. GBB is the \u003cstrong\u003eimmediate metabolic precursor of L-Carnitine\u003c\/strong\u003e in the endogenous biosynthetic pathway: GBB + oxygen + vitamin C → L-Carnitine, catalyzed by γ-butyrobetaine dioxygenase (BBD). Supplementation with GBB provides the immediate substrate for endogenous L-Carnitine synthesis, increasing plasma and muscle levels of L-Carnitine more efficiently than oral L-Carnitine (which has limited intestinal absorption by OCTN2 transporters, which quickly saturate). Greater L-Carnitine availability means greater transport of long-chain fatty acids into the mitochondrial matrix via CPT1\/CPT2, increasing β-oxidation and ATP production from fat. In addition to the carnitine synthesis pathway, GBB has a direct and very marked thermogenic effect: it is the thermogenic with the most documented sweating effect reported by users — GBB activates cutaneous temperature receptors and significantly increases sweating, which is a direct marker of thermogenesis (heat production). Users of Lipo-6 Black Intense consistently report greater sweating during exercise and a greater sensation of body heat than with other fat burners — GBBGO® is primarily responsible for this effect.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e~250mg of caffeine per capsule: high-performance dose in a single Liqui-Cap:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWith \u003cstrong\u003e~250mg of anhydrous caffeine per capsule\u003c\/strong\u003e (confirmed by multiple sources as \"about 250mg per dose\"), Lipo-6 Black Intense has 25% more caffeine than UC (200mg) and is one of the highest caffeine doses per capsule available on the European supplement market. For context: 250mg of caffeine is equivalent to approximately 2 to 3 strong espresso coffees. Liqui-Cap technology ensures that this dose of caffeine is absorbed within 10 to 20 minutes of ingestion, producing a very rapid onset of energy and alertness. Combined with the total 315.1mg of the proprietary blend (which includes theobromine for prolonged sustenance), the energy curve of Intense is the most intense and prolonged of the entire Lipo-6 line.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAdipoSyn™ (Citrus aurantium 50% p-Synephrine): the certified thermogenic shared with UC:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the \u003cstrong\u003eLipo-6 Black Ultra Concentrate\u003c\/strong\u003e section, \u003cstrong\u003eAdipoSyn™\u003c\/strong\u003e (Advantra Z® in earlier versions, AdipoSyn™ in more recent versions) is the Citrus aurantium extract standardized to 50% p-synephrine — the highest concentration available on the market and with the largest volume of published clinical studies among synephrine extracts. p-synephrine activates β3-adrenergic receptors in adipocytes (lipolysis and thermogenesis via UCP1) without the marked cardiovascular effects of ephedrine. In the context of Intense, AdipoSyn™ synergizes with caffeine (which amplifies norepinephrine release), GBBGO® (which increases mitochondrial β-oxidation of mobilized fatty acids), and yohimbine\/rauwolscine (which blocks the α2 brake on lipolysis), creating the most complete lipolytic and thermogenic cycle available in a single capsule.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eYohimbine HCl + Rauwolscine: dual-potency α2 blockade (shared with UC):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs extensively described in the Lipo-6 Black and Lipo-6 Black Ultra Concentrate sections, the \u003cstrong\u003eYohimbine HCl + Rauwolscine\u003c\/strong\u003e (90% alpha-yohimbine) combination blocks α2-adrenergic receptors in adipocytes, mobilizing stubborn subcutaneous fat from areas with higher α2 density (lower abdomen, flanks, thighs). In Intense, α2 blockade is combined with 250mg of caffeine (greater norepinephrine release) + GBBGO® (greater mitochondrial β-oxidation) + AdipoSyn™ (greater β3 activation) — the most potent synergy possible among the ingredients in the Lipo-6 line.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAnhydrous Theobromine: sustained thermogenic support:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the Lipo-6 Black and UC sections, theobromine complements caffeine with a milder but much longer-lasting thermogenic and vasodilating effect (half-life 7 to 12 hours), preventing an abrupt crash and sustaining elevated metabolic expenditure throughout the entire afternoon and evening of training.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take \u003cstrong\u003e1 capsule in the morning\u003c\/strong\u003e and \u003cstrong\u003e1 capsule in the afternoon\u003c\/strong\u003e, at least 30 minutes before a meal. \u003cstrong\u003eNEVER exceed 1 capsule per serving. NEVER take more than 2 capsules in 24 hours.\u003c\/strong\u003e Do not take within 6 hours of bedtime. To assess initial tolerance, start with 1 capsule only in the morning for the first 3 to 5 days before progressing to 2 capsules\/day. \u003cstrong\u003eUse in cycles: maximum 60 days of use + 15 days break.\u003c\/strong\u003e 60 capsules = 30 days of use (at 2 capsules\/day).\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52705354449243,"sku":null,"price":39.99,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/Nutrex-Lipo6Intense.png?v=1777586680"},{"product_id":"nutrex-research-lipo-6-black-120caps","title":"Nutrex - Lipo 6 Black | 120 capsules","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 Black is one of the most \u003cstrong\u003eiconic and recognized fat burners\u003c\/strong\u003e on the global supplementation market, with decades of history and millions of users. Formulated with \u003cstrong\u003e9 active ingredients in confirmed dosages\u003c\/strong\u003e — delivered in liquid gel capsules (Liqui-Caps) for ultra-fast absorption — Lipo-6 Black simultaneously covers all aspects of fat loss: thermogenesis, lipolysis (mobilization of stored fat), appetite suppression, energy and cognitive focus, and unlocking stubborn subcutaneous fat (via yohimbine and alpha-yohimbine). Nutrex's exclusive \u003cstrong\u003eLiqui-Cap\u003c\/strong\u003e technology pre-dissolves the active ingredients in a liquid medium inside the capsule, allowing for faster gastric and intestinal absorption than conventional tablets or capsules. \u003cstrong\u003e120 liquid-caps. Dosage: 3 capsules in the morning + 3 capsules in the afternoon (maximum 6\/day), without food.\u003c\/strong\u003e Vegan (HPMC capsules).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIngredients per serving (3 capsules):\u003c\/strong\u003e Choline Bitartrate 100mg + L-Tyrosine 250mg + Caffeine Anhydrous 220mg + Theobromine 125mg + Grains of Paradise (Aframomum melegueta) 25mg + Black Pepper Extract (BioPerine®) 5mg + Yohimbine HCl 3mg + Rauwolscine (90% alpha-yohimbine) 1mg + Huperzine-A 1% 100mcg. Other ingredients: Glycerin + Vegetable Capsule (HPMC) + Purified water + FD\u0026amp;C Colorants.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLiqui-Cap Technology: the liquid absorption that sets Lipo-6 Black apart from conventional thermogenics:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex's \u003cstrong\u003eLiqui-Cap\u003c\/strong\u003e technology is the central technological differentiator of Lipo-6 Black compared to most conventional encapsulated fat burners (which contain pressed dry powder). The active ingredients of Lipo-6 Black are pre-dissolved in a liquid medium (glycerin + purified water) inside the vegetable gel capsule. When the capsule dissolves in the stomach (typically in 5 to 10 minutes, vs. 20 to 30 minutes for compressed powder capsules), the ingredients are already in solution and are immediately absorbed by the gastric and intestinal mucosa without the need for additional dissolution. This faster absorption translates into a faster onset of effect (perceptible energy and thermogenesis in 15 to 20 minutes vs. 30 to 45 minutes for conventional tablets) and potentially higher bioavailability for ingredients that have limited absorption in solid form.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCaffeine Anhydrous 220mg + Theobromine 125mg: the stimulant duo with a smooth energy profile:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe combination of \u003cstrong\u003eCaffeine Anhydrous\u003c\/strong\u003e (220mg) and \u003cstrong\u003eTheobromine\u003c\/strong\u003e (125mg) is the energetic and thermogenic core of Lipo-6 Black, and it is one of the most clinically well-documented stimulant duos on the market. Caffeine (220mg per 3-capsule dose, 440mg total\/day in double doses) inhibits phosphodiesterase (increasing cAMP), antagonizes adenosine receptors (fatigue suppression), activates the sympathetic nervous system (thermogenesis and adrenergic lipolysis), and suppresses appetite via dopaminergic and adrenergic antagonism. \u003cstrong\u003eTheobromine\u003c\/strong\u003e (derived from cocoa, 3,7-dimethylxanthine) is a xanthine with a similar structure to caffeine but with milder and longer-lasting effects: a half-life of 7 to 12 hours (vs. 3 to 5 hours for caffeine), lower affinity for adenosine receptors (less central stimulant), but peripheral vasodilation (via inhibition of vascular phosphodiesterase) and prolonged thermogenesis. The combination creates a two-phase energy profile: a rapid and intense onset from caffeine + a long and smoother sustain from theobromine, without the typical \"crash\" of isolated caffeine.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGrains of Paradise (Aframomum melegueta) 25mg: the activation of brown adipose tissue:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGrains of Paradise\u003c\/strong\u003e (a relative of cardamom) is the most innovative thermogenic ingredient in Lipo-6 Black and its main differentiator from conventional fat burners based solely on caffeine + synephrine. Its active compound, \u003cstrong\u003e6-paradol\u003c\/strong\u003e (and related 6-gingerol and 6-shogaol), activates β3-adrenergic receptors in \u003cstrong\u003ebrown adipose tissue (BAT)\u003c\/strong\u003e, stimulating non-shivering thermogenesis via mitochondrial uncoupling (UCP1 — Uncoupling Protein 1). Brown adipose tissue \"burns\" energy as heat instead of storing triglycerides, unlike white adipose tissue. The study by Sugita et al. (2014), published in the British Journal of Nutrition, documented that 40mg\/day of Grains of Paradise extract for 4 weeks increased resting energy expenditure and reduced visceral abdominal fat in young women compared to placebo, without significant cardiovascular side effects.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eYohimbine HCl 3mg + Rauwolscine 1mg: unlocking stubborn subcutaneous fat via α2-adrenergic antagonism:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe combination of \u003cstrong\u003eYohimbine HCl\u003c\/strong\u003e (yohimbine, alkaloid from Pausinystalia yohimbe) and \u003cstrong\u003eRauwolscine\u003c\/strong\u003e (alpha-yohimbine, alkaloid from Rauwolfia vomitoria, standardized to 90%) is the most potent and differentiating component of Lipo-6 Black for mobilizing \"stubborn\" subcutaneous fat — fat areas resistant to lipolysis such as the lower abdomen, flanks, and thighs in men, and hips, thighs, and buttocks in women. Fat in these areas has a high density of \u003cstrong\u003eα2-adrenergic receptors\u003c\/strong\u003e (which inhibit hormone-sensitive lipase and block lipolysis when activated by noradrenaline), making it resistant to mobilization even with severe caloric deficit. Yohimbine and alpha-yohimbine are \u003cstrong\u003eα2-adrenergic receptor antagonists\u003c\/strong\u003e — by blocking these receptors, they remove the anti-lipolytic \"brake\" that keeps stubborn subcutaneous fat trapped in adipocytes, allowing its mobilization by noradrenaline and adrenaline in the α2-blocked phases. \u003cstrong\u003eRauwolscine\u003c\/strong\u003e (alpha-yohimbine) has a higher affinity and potency for the α2 receptor than conventional yohimbine, making it more effective per mg. The combination of the two forms is synergistic: yohimbine covers conventional α2 blockade, rauwolscine adds greater potency and duration.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCholine Bitartrate 100mg: hepatic fat metabolism and cholinergic focus:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs described in the \u003cstrong\u003ePower M.F\u003c\/strong\u003e section of Marvelous Nutrition, \u003cstrong\u003eCholine Bitartrate\u003c\/strong\u003e is a precursor to acetylcholine (for focus, neuromuscular transmission, and mind-muscle connection) and supports hepatic fat metabolism (choline is essential for the formation of VLDL which exports triglycerides from the liver to tissues). In the context of prolonged caloric deficit, choline support prevents hepatic steatosis (fat accumulation in the liver) that can occur with increased mobilization of fatty acids to the liver without sufficient choline for export via VLDL.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eL-Tyrosine 250mg: catecholaminergic support during the cutting phase:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs described in \u003cstrong\u003eAmputation\u003c\/strong\u003e by Marvelous Nutrition, L-Tyrosine replenishes the substrate for the synthesis of dopamine, noradrenaline, and adrenaline — catecholamines whose synthesis can be compromised during prolonged periods of caloric restriction. The dose of 250mg per serving (500mg\/day total) is a moderate and clinically relevant dose for cognitive and motivational support during caloric deficit.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBioPerine® 5mg: maximized absorption of all ingredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBioPerine®\u003c\/strong\u003e (black pepper extract standardized to 95% piperine, a registered trademark of Sabinsa Corporation) is the absorption enhancer included in almost all high-quality thermogenics. As described in multiple previous products, piperine inhibits first-pass metabolism enzymes (CYP3A4, UGT) and efflux proteins (P-gp) in the intestinal epithelium, increasing the bioavailability of multiple active compounds by 20 to 2000%.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHuperzine-A 1% 100mcg: cognitive focus via acetylcholinesterase inhibition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHuperzine-A\u003c\/strong\u003e (an alkaloid from the moss Huperzia serrata, extracted at 1% concentration) is a reversible inhibitor of acetylcholinesterase (AChE) — the enzyme that degrades acetylcholine in the synaptic cleft. By inhibiting AChE, Huperzine-A prolongs and amplifies the cholinergic signal, improving cognition, working memory, focus, and mental clarity. This cognitive effect is especially relevant during intense cutting phases with severe caloric deficit, where cognitive decline and difficulty concentrating are common. Huperzine-A has a long half-life (~10 to 14 hours) and accumulates with daily use — it requires the 8-week on + 4-week off cycle indicated in the Lipo-6 Black instructions to avoid desensitization.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take 3 capsules in the morning and 3 capsules in the afternoon, without food (at least 30 minutes before a meal or 1 hour after). Never take more than 6 capsules in 24 hours. Do not take within 6 hours before bedtime (caffeine + theobromine can impair sleep). Use in cycles: maximum 60 days of continuous use followed by 15 days off (some protocols indicate 8 weeks on + 4 weeks off). For caffeine-sensitive users: start with 1 capsule in the morning and 1 in the afternoon and progressively increase as tolerated.\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52861659119963,"sku":null,"price":24.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/Nutrex-Lipo6Black.png?v=1777586441"},{"product_id":"nutrex-lipo-6-hardcore","title":"Nutrex - Lipo 6 Hardcore | 60caps","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 Hardcore is the \u003cstrong\u003enext-generation fat burner in the Lipo-6 line\u003c\/strong\u003e, with a completely reformulated and different blend from its predecessors UC and Intense — replacing theobromine and synephrine with more innovative and unconventional ingredients: \u003cstrong\u003eCocoabuterol®\u003c\/strong\u003e (concentrated Theobroma cacao extract with 50% total cocoa alkaloids), \u003cstrong\u003eCapsicum annuum\u003c\/strong\u003e (2% capsaicin for thermogenesis via TRPV1), \u003cstrong\u003eKanna\u003c\/strong\u003e (Sceletium tortuosum, the South African adaptogen for appetite suppression and mood enhancement) and \u003cstrong\u003eGBBGO®\u003c\/strong\u003e (L-Carnitine precursor) — all combined with \u003cstrong\u003e~300mg of anhydrous caffeine\u003c\/strong\u003e (the highest dose in the Lipo-6 line) and \u003cstrong\u003eRauwolscine 90%\u003c\/strong\u003e. No Liqui-Cap — solid vegetable cellulose capsules. Vegan. 60 capsules, 30 days of use (2 capsules\/day).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIngredients per capsule (proprietary blend):\u003c\/strong\u003e Anhydrous Caffeine (~300mg) + Cocoabuterol® (Theobroma cacao L., seed, min. 50% cocoa alkaloids) + Capsicum annuum Extract (2% capsaicin) + Kanna (Sceletium tortuosum, 10:1) + GBBGO® (Gamma-Butyrobetaine Hydrochloride) + Rauwolfia vomitoria Extract (root, 90% Rauwolscine). Other ingredients: Microcrystalline cellulose + Vegetable capsule + Magnesium stearate + Silicon dioxide + Chlorophyllin.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eLipo-6 Hardcore in the Nutrex hierarchy: the new generation with distinct ingredients from UC and Intense:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLipo-6 Hardcore represents the evolution of the Lipo-6 line beyond the caffeine + theobromine + synephrine + yohimbine formula that defines UC and Intense. Instead of escalating the same ingredients in higher doses, Hardcore introduces \u003cstrong\u003e3 completely new ingredients\u003c\/strong\u003e to the line: \u003cstrong\u003eCocoabuterol®\u003c\/strong\u003e (total cocoa extract with multiple alkaloids), \u003cstrong\u003eKanna\u003c\/strong\u003e (South African adaptogen and nootropic) and \u003cstrong\u003eCapsicum annuum\u003c\/strong\u003e with capsaicin titrated to 2%. The exclusion of synephrine (Citrus aurantium) and conventional yohimbine HCl (replaced only by rauwolscine 90%) and the introduction of these new ingredients make Hardcore not only \"stronger\" but \u003cstrong\u003equalitatively different\u003c\/strong\u003e from other Lipo-6 products — with a greater focus on thermogenesis via TRPV1 (capsaicin), mood and appetite suppression (Kanna + caffeine) and the activation of multiple cocoa alkaloids (Cocoabuterol®).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e300mg of caffeine per capsule: the highest dose in the Lipo-6 line:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWith \u003cstrong\u003e~300mg of anhydrous caffeine per capsule\u003c\/strong\u003e (confirmed directly by Nutrex Research — the dose is not declared on the label but the brand confirmed 300mg\/dose to multiple retailers and reviewers), Lipo-6 Hardcore has the highest caffeine concentration of the entire Lipo-6 line — higher than UC (200mg) and Intense (~250mg). 300mg of caffeine is equivalent to approximately 3 strong espressos or 2 large cups of filtered coffee. For safety context: EFSA considers doses up to 400mg\/day to be safe for healthy adults, and with 2 capsules\/day Hardcore provides 600mg of total caffeine — at the upper limit of what is considered safe, which justifies the requirement to never exceed 1 capsule\/dose and never more than 2 capsules\/24h.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCocoabuterol® (Theobroma cacao, 50% total alkaloids): the most concentrated cocoa extract on the market:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCocoabuterol®\u003c\/strong\u003e (a registered trademark of NNB Nutrition) is a Theobroma cacao seed extract standardized to a \u003cstrong\u003eminimum of 50% total cocoa alkaloids\u003c\/strong\u003e — the highest concentration commercially available. Cocoa contains a family of alkaloids with thermogenic, lipolytic, and neuroactive properties: \u003cstrong\u003etheobromine\u003c\/strong\u003e (the most abundant alkaloid, ~1 to 4% of dry mass), \u003cstrong\u003ecaffeine\u003c\/strong\u003e (~0.2 to 0.5%), \u003cstrong\u003etheophylline\u003c\/strong\u003e (bronchodilator and weak stimulant), \u003cstrong\u003ephenylethylamine (PEA)\u003c\/strong\u003e (neuromodulator with effects on mood and focus), and multiple cocoa flavonoids (epicatechin, catechin, procyanidins) with vasodilatory and antioxidant effects. Cocoabuterol® standardized to 50% total alkaloids contains significantly higher doses of all these compounds compared to conventional cocoa powder (2 to 4% alkaloids) or isolated pure theobromine. The combination of theobromine + theophylline + PEA from Cocoabuterol® with the anhydrous caffeine from Hardcore creates a richer and more nuanced stimulating and thermogenic profile than the simple addition of isolated anhydrous theobromine used in UC and Intense.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCapsicum annuum 2% capsaicin: thermogenesis via TRPV1 activation and appetite suppression:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCapsicum annuum Extract\u003c\/strong\u003e standardized to 2% capsaicin is the thermogenic ingredient in Hardcore via TRPV1 (Transient Receptor Potential Vanilloid 1) — analogous to the effect of cayenne pepper described in multiple previous products in this session (Stage, Thermo Full, Power M.F). Capsaicin activates TRPV1 receptors in the afferent nerve fibers of the gastrointestinal mucosa and skin, triggering a reflex response from the sympathetic nervous system that increases thermogenesis and fat oxidation. In addition to the thermogenic effect, capsaicin has documented \u003cstrong\u003eappetite-suppressing properties\u003c\/strong\u003e: it reduces caloric intake in subsequent meals after administration via gastrointestinal mechanisms (reduction of gastric emptying and increased feeling of satiety via CCK and GLP-1). Standardization to 2% capsaicin ensures a reproducible active dose per capsule.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eKanna (Sceletium tortuosum 10:1): the South African adaptogen for mood, focus, and appetite suppression:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eKanna\u003c\/strong\u003e (Sceletium tortuosum, a succulent plant from South Africa) is the most unusual and innovative ingredient in the Lipo-6 line — rarely found in conventional fat burners. Used for centuries by the Khoikhoi and San peoples of South Africa as a masticatory to reduce hunger, fatigue, and anxiety during long hunts, Kanna's active compounds are \u003cstrong\u003emesembrine alkaloids\u003c\/strong\u003e (PDE4 inhibitors that increase intracellular cAMP) and \u003cstrong\u003emesembrenols\u003c\/strong\u003e (serotonin reuptake transporter, SERT inhibitors). Kanna thus combines two distinct neuroactive mechanisms: PDE4 inhibition (the same mechanism as caffeine, but more selective for the central nervous system) and serotonin reuptake inhibition (serotonergic effect similar to SSRIs but with reduced potency). Documented practical effects include: improved mood and reduced anxiety (especially relevant for athletes on prolonged caloric restriction, where mood and motivation are often compromised), improved focus and cognition, and appetite suppression (via serotonergic mechanisms — serotonin has documented anorexigenic effects). The 10:1 extract ensures a high concentration of mesembrine per capsule.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGBBGO® (Gamma-Butyrobetaine): the thermogenic \"super carnitine\" (shared with Intense):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the \u003cstrong\u003eLipo-6 Black Intense\u003c\/strong\u003e section, \u003cstrong\u003eGBBGO®\u003c\/strong\u003e is the immediate precursor of endogenous L-Carnitine that increases plasma and muscle levels of L-Carnitine more effectively than oral L-Carnitine, enhancing the transport of fatty acids to the mitochondria and thermogenesis. In Hardcore, GBBGO® combines with capsaicin (thermogenesis via TRPV1) and Cocoabuterol® (thermogenesis via cocoa alkaloids + PEA) to create a thermogenic stack with 3 distinct mechanical pathways — more diversified than previous products in the line.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRauwolscine 90% (without yohimbine HCl): the purified α2 blockade:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eHardcore uses only \u003cstrong\u003eRauwolscine\u003c\/strong\u003e (alpha-yohimbine, Rauwolfia vomitoria, 90% purity) as an α2 antagonist — without conventional yohimbine HCl. This choice is consistent with the \"new generation\" philosophy: rauwolscine has a higher affinity for the α2 receptor than conventional yohimbine and lower activity on other adrenergic subtypes (α1, β1, β2) — which means greater lipolytic specificity with a lower risk of unwanted cardiovascular effects. For athletes who responded well to rauwolscine but experienced side effects with conventional yohimbine (anxiety, hypertension, tachycardia), the substitution with pure rauwolscine is an advantage.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take \u003cstrong\u003e1 capsule in the morning\u003c\/strong\u003e and \u003cstrong\u003e1 capsule in the afternoon\u003c\/strong\u003e, between meals (do not take with food). \u003cstrong\u003eNEVER exceed 1 capsule per dose. NEVER take more than 2 capsules in 24 hours.\u003c\/strong\u003e Do not take within 6 hours before bedtime. To assess tolerance, start with 1 capsule only in the morning for 3 to 5 days. Use in cycles: \u003cstrong\u003emaximum 60 days of use + 30 days break\u003c\/strong\u003e (longer break than other Lipo-6 products — 30 days vs. 15 days — indicated by Nutrex for Hardcore). 60 capsules = 30 days of use.\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52901388026203,"sku":null,"price":26.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/1_81733cf0-9b55-48f9-bc97-54a0b2ab41fe.png?v=1780698818"},{"product_id":"nutrex-lipo-6-cla-1000-90caps","title":"Nutrex - Lipo 6 CLA 1000 | 90caps","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 CLA 1000 is a \u003cstrong\u003ehighly concentrated Conjugated Linoleic Acid (CLA)\u003c\/strong\u003e supplement in fast-absorbing softgels, with \u003cstrong\u003e1000mg of CLA Active Blend per softgel\u003c\/strong\u003e yielding \u003cstrong\u003e80% pure CLA\u003c\/strong\u003e derived from \u003cstrong\u003esafflower oil\u003c\/strong\u003e — equivalent to 800mg of biologically active CLA per softgel. Completely stimulant-free, no caffeine, no synephrine, no yohimbine — the purest and most convenient body composition supplement in the Nutrex portfolio for standalone use or stacked with any stimulating fat burner from the Lipo-6 line. \u003cstrong\u003e180 softgels (90 doses of 2 softgels\/day = 90 days of use).\u003c\/strong\u003e Not vegan (gelatin). 1 softgel in the morning + 1 softgel in the evening with a meal.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eIngredients:\u003c\/strong\u003e CLA Active Blend 1000mg (yielding 80% CLA from safflower oil\/Carthamus tinctorius). Other ingredients: Gelatin + Purified Water + Glycerin + Carob extract.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCLA (Conjugated Linoleic Acid): the most studied body composition fatty acid in supplement history:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCLA\u003c\/strong\u003e (Conjugated Linoleic Acid) is a family of positional and geometric isomers of linoleic acid (C18:2), naturally found in the fat of meat and milk from ruminants (especially grass-fed animals, where the CLA concentration can be 3 to 5 times higher than in grain-fed animals). The two most biologically active isomers are \u003cstrong\u003ecis-9, trans-11 CLA\u003c\/strong\u003e (c9,t11, also known as rumenic acid — the dominant isomer in milk and meat, with anti-carcinogenic and immunomodulatory properties) and \u003cstrong\u003etrans-10, cis-12 CLA\u003c\/strong\u003e (t10,c12 — the isomer with greater activity in body composition, especially in reducing fat mass and preserving muscle mass). The CLA from safflower oil (the source used in Lipo-6 CLA, like in most CLA supplements on the market) provides a mixture of c9,t11 and t10,c12 isomers in approximately equal proportions.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003e80% CLA from safflower oil: the premium concentration per softgel:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe \u003cstrong\u003eCLA Active Blend\u003c\/strong\u003e in Lipo-6 CLA is standardized to \u003cstrong\u003e80% total CLA\u003c\/strong\u003e from safflower oil — a significantly higher concentration than economic CLA supplements on the market (often standardized to 60 to 70% CLA). With 1000mg of CLA Active Blend at 80%, each softgel provides \u003cstrong\u003e800mg of biologically active CLA\u003c\/strong\u003e — and at 2 softgels\/day, the total dose is \u003cstrong\u003e1600mg of CLA\/day\u003c\/strong\u003e. Reference meta-analyses on CLA and body composition (Whigham et al., 2007, American Journal of Clinical Nutrition; Onakpoya et al., 2012, Journal of Obesity) used doses of 1.4 to 3.2g\/day of total CLA, with documented fat mass reduction efficacy of ~0.09 kg\/week vs. placebo. The 1.6g\/day dose of Lipo-6 CLA (2 softgels) falls within this documented efficacy window.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCLA mechanisms in body composition: PPAR, LPL, and adipocyte apoptosis:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eCLA (especially the t10,c12 isomer) acts on body composition through multiple convergent mechanisms. The first is the \u003cstrong\u003eactivation of PPAR-α receptors\u003c\/strong\u003e (Peroxisome Proliferator-Activated Receptor alpha) in muscle and liver cells: PPAR-α are nuclear receptors that, when activated by fatty acids (including CLA), regulate the expression of genes involved in mitochondrial β-oxidation of fatty acids — increasing the mitochondria's capacity to oxidize fat as fuel. The second mechanism is the \u003cstrong\u003einhibition of lipoprotein lipase (LPL)\u003c\/strong\u003e in adipocytes: LPL is the enzyme that catalyzes the hydrolysis of circulating triglycerides (in VLDL and chylomicrons) and the subsequent uptake of the resulting fatty acids by adipocytes for re-esterification and storage as fat. CLA t10,c12 inhibits adipocyte LPL, reducing fat accumulation in adipocytes regardless of caloric intake. The third mechanism is the \u003cstrong\u003epromotion of mature adipocyte apoptosis\u003c\/strong\u003e: CLA t10,c12 induces apoptosis (programmed cell death) of adipocytes via caspase activation, reducing the total number of fat cells. These three combined mechanisms explain the effect of reducing fat mass with preservation of muscle mass documented in clinical trials with CLA.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSafflower oil (Carthamus tinctorius): the most concentrated vegetable source of CLA for supplementation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSafflower oil\u003c\/strong\u003e is obtained from the seeds of Carthamus tinctorius, an oil-rich plant from the composite family. The high-linoleic safflower oil variety has a linoleic acid content of 75 to 80% of total fatty acids — much higher than sunflower oil (70%), olive oil (10%), or coconut oil (\u003c5%). The concentration of CLA in non-hydrogenated safflower oil is low (CLA is mainly formed by bacterial biohydrogenation in the rumen of animals, not in plants), so the CLA in the supplement is industrially produced from the linoleic acid of safflower oil by controlled chemical isomerization (conversion of linoleic acid into CLA isomers by alkaline treatment). Safflower oil is the preferred raw material for supplemental CLA production due to its high concentration of linoleic acid (the isomerization substrate) and its clean fatty acid profile.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eStimulant-free: the body composition supplement for any time and anyone:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLipo-6 CLA is \u003cstrong\u003ecompletely stimulant-free\u003c\/strong\u003e — no caffeine, no synephrine, no yohimbine, no adrenergic compounds whatsoever. This makes it suitable for: use at any time of day, including at night; people sensitive to caffeine or with cardiovascular conditions; athletes who already take a stimulating fat burner (Lipo-6 Black, UC, Intense, or Hardcore) and want to add CLA to their stack without increasing the stimulant load; pregnant women (check with doctor); and continued use for prolonged periods without the mandatory cycle restrictions of fat burners with stimulants. CLA can — and should — be taken every day, including rest days without training.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eNutrex's softgel technology: rapid absorption of CLA in a lipid medium:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLipo-6 CLA uses \u003cstrong\u003eliquid-filled gelatin softgels\u003c\/strong\u003e — the same philosophy as Nutrex's Liqui-Caps applied to CLA. CLA in liquid softgel form has faster and more complete intestinal absorption than CLA in dry powder capsules or tablets: CLA is a fatty acid and as such is absorbed by biliary micelles in the small intestine along with dietary fats. Absorption is maximized when the softgel is taken with a meal containing some dietary fat (which stimulates the secretion of bile and pancreatic lipase necessary for fatty acid absorption).\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dosage:\u003c\/strong\u003e Take 1 softgel in the morning and 1 softgel in the evening, preferably with a meal. To maximize absorption, take with meals containing fat. Can be taken every day including non-training days — CLA has a cumulative effect and requires consistent use for 4 to 8 weeks to produce measurable results in body composition. 180 softgels = 90 doses of 2 softgels = 90 days of use.\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52901392679259,"sku":null,"price":19.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/Nutrex-Lipo6CLA1000.webp?v=1777587105"},{"product_id":"nutrex-lipo-6-stim-free-60caps","title":"Nutrex - Lipo 6 Stim-Free | 60 caps","description":"\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eAbout the Product\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eNutrex Research's Lipo-6 Stim-Free is the \u003cstrong\u003ecompletely stimulant-free fat burner\u003c\/strong\u003e from the Lipo-6 line — formulated with \u003cstrong\u003e6 active ingredients\u003c\/strong\u003e for thermogenesis, AMPK activation, glycemic management, and lipolysis support, without any caffeine, theobromine, synephrine, yohimbine, or any other adrenergic stimulant. Designed for caffeine-sensitive athletes, for nighttime workouts without impacting sleep, or for stacking with any stimulant fat burner from the Lipo-6 line (UC, Intense, Hardcore) without duplicating stimulants. The 6 ingredients are: \u003cstrong\u003eGrains of Paradise (Aframomum melegueta)\u003c\/strong\u003e — brown adipose tissue (BAT) activation, \u003cstrong\u003eGBBGO®\u003c\/strong\u003e — L-Carnitine precursor and thermogenic, \u003cstrong\u003eGynostemma pentaphyllum\u003c\/strong\u003e — AMPK activator, \u003cstrong\u003eHesperidin\u003c\/strong\u003e — lipid metabolism support, \u003cstrong\u003eChromium Picolinate\u003c\/strong\u003e — glycemic control and craving management, \u003cstrong\u003eBioPerine®\u003c\/strong\u003e — maximized absorption. HPMC vegetable capsules. Vegan. 60 capsules. 1 capsule in the morning + 1 capsule in the afternoon\/evening, on an empty stomach.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eBenefits\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eThe stimulant-free fat burner for any time, any athlete, any stack:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eLipo-6 Stim-Free is Nutrex's solution for 4 distinct user profiles who cannot or do not want to use stimulants: athletes sensitive to caffeine or with cardiovascular conditions that contraindicate stimulants; athletes who train at night and do not want to compromise sleep with 200 to 300mg of caffeine; athletes who already take a stimulant fat burner from the Lipo-6 line (UC, Intense, or Hardcore) and want to add stimulant-free metabolic support to maximize results without overtaxing the sympathetic nervous system; and athletes in maintenance phases or between cycles of stimulant fat burners (which require mandatory breaks) who want to maintain continuous stimulant-free metabolic support.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGrains of Paradise (Aframomum melegueta): brown adipose tissue (BAT) activation without stimulants:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the \u003cstrong\u003eLipo-6 Black\u003c\/strong\u003e standard section (which also includes Grains of Paradise), \u003cstrong\u003e6-paradol\u003c\/strong\u003e and related compounds from Aframomum melegueta activate the β3-adrenergic receptors of \u003cstrong\u003ebrown adipose tissue (BAT)\u003c\/strong\u003e, stimulating non-shivering thermogenesis via mitochondrial uncoupling (UCP1). BAT \"burns\" energy as heat instead of storing it as triglycerides — it is the body's thermogenic system. The study by Sugita et al. (2014), published in the Journal of Nutritional Science and Vitaminology with 19 healthy young men, documented that daily intake of 40mg of Grains of Paradise extract for 4 weeks increased resting energy expenditure and reduced visceral abdominal fat compared to placebo. In the Stim-Free context, Grains of Paradise is the ingredient that best mimics the thermogenic effect of caffeine\/synephrine without being an adrenergic stimulant.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGBBGO® (Gamma-Butyrobetaine): the \"super precursor\" of L-Carnitine for thermogenesis and β-oxidation:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the \u003cstrong\u003eLipo-6 Black Intense\u003c\/strong\u003e and \u003cstrong\u003eLipo-6 Hardcore\u003c\/strong\u003e sections, \u003cstrong\u003eGBBGO®\u003c\/strong\u003e is the immediate precursor of L-Carnitine in the endogenous biosynthetic pathway. By increasing plasma and tissue levels of L-Carnitine, GBBGO® enhances the transport of long-chain fatty acids across the inner mitochondrial membrane via CPT1\/CPT2, increasing β-oxidation and ATP production from fat. In Lipo-6 Stim-Free, GBBGO® adds thermogenesis and lipolysis via pathways completely independent of adrenergic receptors — which is why Stim-Free can partially reproduce the thermogenic effects of stimulant products without using any stimulants.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGynostemma pentaphyllum (leaf extract): the AMPK activator for fat metabolism and cellular longevity:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGynostemma pentaphyllum\u003c\/strong\u003e (jiaogulan, the \"immortality herb\" in traditional Chinese medicine) is a climbing plant from the Cucurbitaceae family whose leaf extracts are rich in \u003cstrong\u003egynosaponins\u003c\/strong\u003e (triterpenic saponins with a structure similar to ginseng ginsenosides) with documented activity as \u003cstrong\u003eAMPK activators\u003c\/strong\u003e (AMP-activated protein kinase). AMPK is the central metabolic sensor of cells — the \"energy deprivation protein kinase\" — which, when activated (as occurs during exercise, caloric restriction, or glucose deprivation), promotes fatty acid β-oxidation, inhibits fatty acid and cholesterol synthesis (via inhibition of acetyl-CoA carboxylase and HMG-CoA reductase), increases muscle glucose uptake (via GLUT4 translocation), and stimulates mitochondrial biogenesis (via PGC-1α). AMPK activation by Gynostemma partly mimics the metabolic effects of exercise and caloric restriction — hence its description as \"exercise in a capsule.\" The clinical trial by Park et al. (2014), published in Obesity with 80 obese adults for 12 weeks, documented that Gynostemma extract significantly reduced visceral fat, BMI, and abdominal circumference compared to placebo.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHesperidin: the citrus flavonoid for lipid metabolism and vascular support:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHesperidin\u003c\/strong\u003e (the main glucosidic flavanone of citrus peels — especially bitter orange and sweet orange) is a flavonoid with multiple biological activities relevant to body composition. It acts synergistically with Gynostemma for AMPK activation (hesperidin has independent AMPK activity via flavonoid mechanisms), has anti-inflammatory effects (NF-κB inhibition), antioxidant properties (free radical scavenging and metal chelation), and vasodilator effects (improved microcirculation via endothelial eNOS activation). In the context of a fat burner, hesperidin contributes to improving the lipid profile (reduction of triglycerides and LDL in preclinical studies) and improving peripheral blood flow (relevant for the delivery of oxygen and mobilized fatty acids to muscle tissues for oxidation).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eChromium Picolinate: craving and glycemic management:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs already described in the \u003cstrong\u003eRecharge\u003c\/strong\u003e (Marvelous), \u003cstrong\u003eSuper Digestive\u003c\/strong\u003e, and \u003cstrong\u003eAmputation\u003c\/strong\u003e sections, \u003cstrong\u003echromium picolinate\u003c\/strong\u003e improves insulin receptor sensitivity via chromodulin, supporting glucose uptake by target tissues and preventing post-prandial glycemic spikes. In the context of Lipo-6 Stim-Free, chromium has a specific function: \u003cstrong\u003ecravings\u003c\/strong\u003e (intense desire for sugary or processed foods) are often triggered by fluctuations in blood sugar — reactive post-prandial hypoglycemia triggers the desire to consume high-GI carbohydrates to quickly restore blood sugar. Chromium, by stabilizing blood sugar and improving insulin sensitivity, attenuates these fluctuations and reduces cravings, making it easier to maintain the caloric deficit necessary for fat loss.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBioPerine® 5mg: maximized absorption of all ingredients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAs described in multiple products, \u003cstrong\u003eBioPerine®\u003c\/strong\u003e (black pepper extract, 95% piperine, Sabinsa Corporation) inhibits first-pass metabolism enzymes (CYP3A4, UGT) and efflux proteins (P-gp) in the intestinal epithelium, increasing the bioavailability of multiple active compounds — especially flavonoids like hesperidin (which have naturally low oral bioavailability) and Gynostemma gynosaponins.\u003c\/p\u003e\n\u003ch3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\"\u003eUsage\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eRecommended dose:\u003c\/strong\u003e Take 1 capsule in the morning and 1 capsule in the afternoon or evening, on an empty stomach (at least 30 minutes before a meal or 1 hour after). Stimulant-free — can be taken at night without impacting sleep, making it ideal for nighttime workouts or for continuous use in longer cycles than stimulant fat burners. For stacking with stimulant fat burners from the Lipo-6 line, take Stim-Free during periods when you are not taking the stimulant (e.g., at night), or take simultaneously to maximize metabolic support without adding stimulants. Continuous use for 60 to 90 days recommended for measurable effects.\u003c\/p\u003e","brand":"Nutrex Research","offers":[{"title":"Default Title","offer_id":52901392908635,"sku":null,"price":24.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/files\/Nutrex-Lipo6Stim-Free.png?v=1777587402"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1005\/0250\/3771\/collections\/Nutrex.jpg?v=1778532778","url":"https:\/\/brothers-club.com\/en\/collections\/nutrex-research.oembed","provider":"Brother's Club","version":"1.0","type":"link"}